Sökning: "halogen bonding"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden halogen bonding.

  1. 1. Characterising Halogen Bonding in a Cooperative Model System

    Författare :Stefan Peintner; Mate Erdelyi; Anja Sandström; Uppsala universitet; []
    Nyckelord :Halogen Bond; NMR; peptide; conformation; RDC; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Sammanfattning : Non-covalent interactions are the main driving factor for secondary structure formation of biomacromolecules and are of enormous importance for the direction of molecular recognition events, for example those of importance for drug discovery. Profound understanding of these interactions is of vital importance to achieve high affinity and selectivity of a ligand to a chosen target. LÄS MER

  3. 2. Reactivity of late transition metal complexes towards CO2 and other electrophiles

    Författare :Magnus Johnson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; CO2; carbon dioxide; electrophiles; late transition metal complexes; catalysis; halogen bonding; XB; cyclometallation; pincer; organometallic synthesis;

    Sammanfattning : In times when dwindling energy resources is a major long-term problem for sustaining modern infrastructure and technologies, we need to focus on more enduring solutions. A key contribution to this achievement is catalysis. LÄS MER

  4. 3. The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development

    Författare :Emma Danelius; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; cyclic peptides; NMR; solution conformational analysis; NAMFIS; β-hairpin; weak interactions; halogen bonding; protein-protein interaction; bioactive conformation; macrolides; cell permeable conformation.;

    Sammanfattning : Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles have attractive pharmaceutical properties, and are of special interest as drug leads for targets with large, flat and featureless binding sites like protein-protein interfaces. LÄS MER

  5. 4. Investigation of [N-X-N]+ and [N-C-N]+ complexes in solution : Exploring Geometry, Stability and Symmetry

    Författare :Alavi Karim; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; three center four electron; halonium; carbenium; carbonium; pentavalent; symmetry; NMR; variable temperature; counterion; isotopic perturbation of equilibrium;

    Sammanfattning : Halogen bonding is a weak interaction. In this thesis the three center four electron halogen bond, [N−X−N]+, has been studied. The lighter halogens form highly unstable halonium ions that are reactive towards nucleophiles and their complexes were therefore investigated at low temperatures. LÄS MER

  7. 5. Design, Synthesis and Thermodynamic Studies of Galectin Ligands

    Författare :Maria Luisa Verteramo; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; galectin; conformational entropy; solvation; thermodynamic; interaction; molecular recognition; thiodigalactoside; diastereomer; structure-based design;

    Sammanfattning : The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. LÄS MER