Sökning: "glypican"
Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet glypican.
1. Characterization and Crystallization of Anchorless Glypican-1
Sammanfattning : Glypicans are cell-surface heparan sulfate proteoglycans that regulate Wnt, Hedgehog, bone morphogenetic protein, and fibroblast growth factor signaling through their heparan sulfate chains. Recent studies have shown that glypican core proteins also have functional roles in growth factor signaling, but biochemical and structural knowledge regarding the core proteins is limited. LÄS MER
2. Biosynthesis of decorin and glypican glycosaminoglycan chains
Sammanfattning : Proteoglycans consist of core proteins substituted with glycosaminoglycan chains. The galactosaminoglycans (GlcUA/IdoUA-GalNAc) and the glucosaminoglycans (GlcUA/IdoUA-GlcNAc) are both initiated on the same tetrasaccharide linkage region GlcUA-Gal-Gal-Xyl-protein. LÄS MER
3. Involvement of Heparan Sulphate Biosynthesis and Turnover in Cell Proliferation. A Novel Role for Nitric Oxide in Recycling of Heparan Sulphate Proteoglycans
Sammanfattning : The present investigation focuses on the role of HS metabolism in cell proliferation. The effect of the HS priming ß-D-xyloside, 2-(6-hydroxynaphthyl)-O-ß-D-xylopyranoside (Xyl-2-Nap-6-OH) on the proliferation of normal and transformed cells was studied. LÄS MER
4. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection
Sammanfattning : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. LÄS MER
5. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
Sammanfattning : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. LÄS MER