Sökning: "glutathione S transferase"

Visar resultat 1 - 5 av 47 avhandlingar innehållade orden glutathione S transferase.

  1. 1. Microsomal glutathione transferase : Species characteristics, catalysis and topology

    Författare :Claes Andersson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The membrane-bound detoxication enzyme microsomal glutathione transferase is localized predominantly in the liver of mammalian species, where it is present in high concentrations in the endoplasmic reticulum and the outer mitochondrial membrane. The enzyme conjugates a broad range of hydrophobic xenobiotics bearing reactive electrophilic centers to glutathione, which facilitates deactivation and excretion. LÄS MER

  3. 2. The significance of glutathione S-transferases in biochemical toxicology : kinetic and binding studies designed to establish a mechanism of action of glutathione S-transferase A from rat liver

    Författare :Inga Jakobson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 3. Studies on hepatic glutathione transferases from rat and man : 1. A kinetic mechanism for glutathione transferase A from rat liver. 2. Transferase µ, a new form of glutathione transferase in human liver

    Författare :Margareta Warholm; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This study of glutathione transferases was undertaken to achieve a better understanding of the catalytic and molecular properties of various isozymes of this group of drug-metabolizing enzymes.The steady-state kinetics of purified glutathione transferase A from rat liver with glutathione (GSH) and 1,2-dichloro- 4-nitrobenzene as substrates, did not follow a simple Michaelis- Menten equation. LÄS MER

  5. 4. The kinetic mechanism of microsomal glutathione transferase 1 (MGST1)

    Författare :Richard Svensson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glutathione; glutathione transferase; enzyme mechanism; pre-steady state kinetics; steady state kinetics; membrane protein; xenobiotic metabolism.;

    Sammanfattning : Microsomal glutathione transferase I (MGST1) is a homotrimeric membrane-bound enzyme involved in detoxication of numerous toxic electrophilic compounds, e.g. halogenated alkenes and arenes, alpha, beta-unsaturated hydrocarbons and peroxides. MGST1 is expressed in large amounts in most organs, which speaks for an important role for this enzyme. LÄS MER

  7. 5. Microsomal glutathione transferase : catalysis, in vitro mutagenesis and heterologous expression

    Författare :Rolf Weinander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microsomal glutathione transferase is a membrane-bound member of the glutathione transferases, a family of multifunctional enzymes involved in the cellular detoxification of xenobiotics and reactive endogenous compounds formed during oxidative stress. Rat liver microsomal glutathione transferase is a trimeric protein with a molecular mass of 17. LÄS MER