Sökning: "glutamic acid decarboxylase autoantibodies"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden glutamic acid decarboxylase autoantibodies.

1. 1. Studies of Autoantibodies in Systemic and Organ-Specific Autoimmune Disease

   Författare :Filip Sköldberg; Olle Kämpe; Fredrik Rorsman; Lars Rönnblom; Eva Landgren; Marie Wahren-Herlenius; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; autoantibodies; autoimmune polyendocrine syndrome type 1; cysteine sulfinic acid decarboxylase; histidine decarboxylase; systemic lupus erythematosus; ahnak; CLLD4; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease, whereas autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal disorder characterized by combinations of organ-specific autoimmune manifestations including hypoparathyroidism and intestinal dysfunction, and may serve as a model for organ-specific autoimmunity. Autoantibodies directed against proteins expressed in the affected tissues are found in both diseases. LÄS MER

3. 2. Autoantibodies as markers of beta-cell autoimmunity in children

   Författare :Hanna Holmberg; Johnny Ludvigsson; Mona Landin-Olsson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Autoantibodies; Beta-cell autoimmunity; Children; Breast-feeding; HLA haplotypes; Insulin gene; Paediatric medicine; Pediatrisk medicin;

   Sammanfattning : Type 1 diabetes (T1D) is a chronic disease caused by destruction of the insulin producing beta-cells in the pancreas. The incidence of T1D has increased rapidly, especially in the Western world and among young children. LÄS MER

4. 3. Organ-specific autoantibodies in Addison's disease and autoimmune polyendocrine syndrome type I

   Författare :Annika Söderbergh; Uppsala universitet; []
   Nyckelord :Medical sciences; Addison s disease; APS I; Down syndrome; AIRE; autoantibodies; autoantigens; autoimmunity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Assessment of autoantibodies is a valuable tool in the diagnostic procedure of autoimmune diseases. The aim of this study was to investigate the prevalence of different autoantibodies and their associations with disease manifestations in patients with Addison's disease and autoimmune polyendocrine syndrome type I (APS I). LÄS MER

5. 4. Immunogenetics of Childhood Type 1 Diabetes in Immigrant Patients in Sweden. Migration Studies on Type 1 Diabetes

   Författare :Ahmed Delli; Celiaki och diabetes; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Type 1 Diabetes; Childhood; Human Leukocyte Antigen HLA ; Islet autoantibodies; Zinc Transporter 8 ZnT8 ; Islet antigen IA2- ; Glutamic Acid Decarboxylase 65 GAD65; Insulin; Migration.;

   Sammanfattning : This thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of diabetes. LÄS MER

7. 5. Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)

   Författare :Magnus Hillman; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; diabetology; secreting systems; Isotype class switch; Endocrinology; LADA; Autoantibodies; Autoimmunity; Type 1 diabetes;

   Sammanfattning : Autoimmune diabetes is characterized by cell mediated autoimmunity against insulin producing beta cells in pancreatic islets. Type 1 diabetes is the major cause of diabetes in children and adolescents and is believed to be mediated by a Thl driven destruction of beta cells. LÄS MER