Sökning: "global proteome analysis"
Visar resultat 1 - 5 av 33 avhandlingar innehållade orden global proteome analysis.
1. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis
Sammanfattning : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. LÄS MER
2. Design of recombinant antibody microarrays for global proteome analysis
Sammanfattning : Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recombinant scFv antibody fragments for large-scale comprehensive proteome analysis. LÄS MER
3. Systems Biology in Saccharomyces cerevisiae. Statistical data analysis and mathematical methods
Sammanfattning : Over the last decade, Systems Biology has emerged as a new paradigm in the study of cellular systems which are characterized from a global perspective; in contrast to the traditional cellular biology, which was focused on specific components of the cell. To this end, a key milestone for the achievement of a global view of biology is the generation and interpretation of different datasets derived from omics technologies; such as Transcriptome and Proteome. LÄS MER
4. Mapping the human proteome using bioinformatic methods
Sammanfattning : The fundamental goal of proteomics is to gain an understanding of the expression and function of the proteome on the level of individual proteins, on the level of defined cell types and on the level of the entire organism. In this thesis, the human proteome is explored using membrane protein topology prediction methods to define the human membrane proteome and by global protein expression profiling, which relies on a complex study of the location and expression levels of proteins in tissues and cells. LÄS MER
5. Global Proteome Survey -Transforming antibody-based affinity proteomics into a global discovery platform
Sammanfattning : Proteomics is expected to generate new insights into biological processes as well as identify novel biomarkers and therapeutic targets since most biological functions are transmitted through proteins. However, due to the complexity displayed by a proteome and inherent limitations associated with current methodologies, proteomic analyses often result in incomplete coverage and inconsistent measurements. LÄS MER
