Sökning: "genomic erosion"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden genomic erosion.
1. Genomic analysis of the process leading up to the extinction of the woolly mammoth
Sammanfattning : Species worldwide are subject to contractions in both abundance and geographical range, and their persistence in a changing environment may thus depend on the ability to survive in small and fragmented populations. Despite the urgent need to understand how extinction works, our knowledge of pre-extinction genetic processes is limited because techniques allowing population and conservation genomics to be studied in wild threatened populations have become available only recently. LÄS MER
2. The use of museum specimens in conservation genomics
Sammanfattning : In the face of an increasing number of species being threatened by extinction, museum collections can constitute a powerful resource for acquiring genomic data of endangered taxa. By utilising datasets that combine genomes from present-day populations with those from historical timepoints, several questions relevant for conservation can be investigated. LÄS MER
3. Hopeful monsters: The role of hybrids in adaptation : The impact of hybridisation and genetic diversity on adaptation to stressful and novel environments
Sammanfattning : Adaptation to novel environments can only occur if natural selection has the raw material to act upon. But small, endangered populations are often genetically depleted, and the acquisition of beneficial de novo mutations often takes too long when population face quick and extreme environmental change. LÄS MER
4. Molecular characterization of the interplay between DNA-PK and TRF2 in telomere protection
Sammanfattning : The genetic material of mammalian cells is organized as linear chromosomes inside their nucleus. In order to preserve genomic stability, mammalian cells have developed several mechanisms to detect and repair DNA lesions that can occasionally occur in the genome. LÄS MER
5. Preserving Genetic Integrity in Reproduction: Insights from Telomere Protection and Sperm Head-Tail Junctions
Sammanfattning : This doctoral thesis embarks on a meticulous exploration of genetic integrity within the expansive domain of reproductive biology. Its overarching objective is to decipher the intricacies that underlie the preservation of hereditary stability across generations. LÄS MER