Sökning: "genome stability"
Visar resultat 11 - 15 av 113 avhandlingar innehållade orden genome stability.
11. Investigating the impacts of Late Pleistocene climate change on Arctic mammals using palaeogenomics
Sammanfattning : The climatic fluctuations of the Late Pleistocene likely had a large impact on the evolutionary history of Arctic species. Palaeogenomics is a useful tool to shed light on how past populations responded to these climatic shifts and the associated ice sheet dynamics and sea level change. LÄS MER
12. Downstream functions of the Sty1 MAPK pathway in S. pombe
Sammanfattning : MAP kinase pathways are involved in the response to environmental changes in eukaryotic cells regulating transcriptional and translational events. In S. LÄS MER
13. Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets
Sammanfattning : Altered tumor metabolism has been described as early as the 1920s, but it was only in recent decades that proteomic and metabolomic studies revealed that the ways in which tumors rewire their nutrient and energy pathways are more diverse and have more implications for treatment outcome than previously thought. There is now a great interest in characterizing promising metabolic targets and identifying novel ways by which to exploit them for cancer treatment. LÄS MER
14. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein
Sammanfattning : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. LÄS MER
15. The Role of Polyadenylation in Human Papillomavirus Type 16 Late Gene Expression
Sammanfattning : High-risk type human papillomaviruses (HPVs) are associated with cancer. HPVs are strictly epitheliotropic and infect basal cell layers, establishing a life cycle strongly linked to the differentiation stage of the infected cells. The viral capsid late genes, L2 and L1, are only expressed in terminally differentiated epithelium. LÄS MER
