Sökning: "genome mapping"

Visar resultat 6 - 10 av 162 avhandlingar innehållade orden genome mapping.

1. 6. Genome Variation in Human Populations : Exploring the Effects of Demographic History and the Potential for Mapping of Complex Traits

   Författare :Åsa Johansson; Ulf Gyllensten; Marta Alarcon; Andrew Clark; Uppsala universitet; []
   Nyckelord :Genetics; genetics; evolution; microsatellie; SNP; selection; linkage disequilibrium; haplotype; Genetik;

   Sammanfattning : A major challenge in human genetics is to understand the genetic variation underlying common diseases. In this thesis, I focus on forces creating differences between individuals and genomic regions, methods for characterizing genomic variation, and the association between genomic and phenotypic variation. LÄS MER

3. 7. Chicken Genomics - Linkage and QTL mapping

   Författare :Per Wahlberg; Leif Andersson; Ruedi Fries; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chicken; quantitative genetics; linkage map; QTL mapping; recombination; long-term selection; Z chromosome; selective sweep; SNP; Genetics; Genetik;

   Sammanfattning : This thesis presents results from genetic studies conducted in the chicken (Gallus gallus). The domestication of chicken is believed to have been initiated approximately 7,000 – 9,000 years ago in Southeast Asia. LÄS MER

4. 8. Quantitative Genetics and Genome Structure in a Wild Population: the Use of a Great Reed Warbler Pedigree

   Författare :Mikael Åkesson; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genome mapping ; AFLP; microsatellite; synteny; heterochiasmy; recombination; chicken; great reed warbler ; bird; Genetics; cytogenetics; Genetik; cytogenetik; Animal ecology; trait correlation ; Djurekologi; animal model ; selection; Djurs anatomi och morfologi; animal morphology; Animal anatomy; heritability;

   Sammanfattning : Long-term studies of birds play an important role in the understanding of quantitative traits in natural populations. The relative ease by which individual birds can be monitored and caught in the wild enable us collect detailed information from individuals throughout their life time, sometimes from several generations in a population. LÄS MER

5. 9. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE

   Författare :Anna-Karin B. Lindqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Systemic lupus erythematosus; complex diseases; genetic susceptibility; linkage analysis; genome scan; candidate gene; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Sammanfattning : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. LÄS MER

7. 10. Mapping genetic diseases in northern Sweden

   Författare :Elisabet Einarsdottir; Dan Holmberg; Gösta Holmgren; Ulf Gyllensten; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; isolated populations; linkage disequilibrium; linkage analysis; genome-wide scan; hereditary sensory and autonomic neuropathy; type 1 diabetes mellitus; type 2 diabetes mellitus; autoimmune thyroid disease; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : The population of northern Sweden has previously been shown to be well suited for the mapping of monogenic diseases. In this thesis we have tested the hypothesis that this population could also be used for efficient identification of risk genes for common diseases. LÄS MER