Sökning: "gene disruption"

Visar resultat 1 - 5 av 138 avhandlingar innehållade orden gene disruption.

1. 1. Computational Modelling of Gene Regulation in Cancer : Coding the noncoding genome

   Författare :Husen Muhammad Umer; Jan Komorowski; Claes Wadelius; Jan Korbel; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Regulatory elements; gene regulation; cancer; motif; integrative database; software solutions for cancer data; Bioinformatics; Bioinformatik;

   Sammanfattning : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. LÄS MER

3. 2. Targeted disruption and subcellular distribution of phospholipase C 3

   Författare :Shu Wang; Uppsala universitet; []
   Nyckelord :Medical sciences; Phosphoinositide specific phospholipase C; sequencing; fluorescence in situ hybridization; gene targeting; earlyembryonic development; electron microscopy; secretory granules; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Internal Medicine; invärtesmedicin;

   Sammanfattning : Phosphatidylinositol specific phospholipase C (PLC) isoforms are key enzymes in the signal transduction pathway that control many cellular processes including cell proliferation, hormone secretion and egg fertilization. The PLCβ3 gene, assigned to the multiple endocrine neoplasia type 1 (MEN1) locus, has been implicated in endocrine tumorigenesis due to the low expression in several endocrine tumors. LÄS MER

4. 3. Surface proteins of Finegoldia magna interacting with the human host

   Författare :Christofer Karlsson; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Finegoldia magna; Gram-positive anaerobic cocci; surface proteins; protease; LL-37; MIG CXCL9; Fibrinogen; adhesion; gene disruption; bacterial aggregation; basement membranes;

   Sammanfattning : Finegoldia magna is a Gram-positive anaerobe and a member of the normal human microflora. This bacterium is also an opportunistic pathogen and isolated from ~10% of all anaerobic infections. Reoccurring taxonomical changes and the anaerobic growth have contributed to the neglect of F. magna. LÄS MER

5. 4. Extracellular serine proteases as virulence factors in nematophagous fungi: Molecular characterization and functional analysis of the PII protease in Arthrobotrys oligospora

   Författare :Johan Åhman; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Aspergillus niger.; Heterologous expression; Over-expression; Gene-disruption; Transformation system; Serine protease; Biological control; Arthrobotrys oligospora; Fungi; Nematophagous; Biologi;

   Sammanfattning : Nematophagous fungi are parasites of nematodes, thus they have been considered and tested for biological control of parasitic nematodes, but so far with limited success. Due to the fact that the nematode cuticle is composed of proteins it is likely that fungal extracellular proteases are involved in the infection of nematodes. LÄS MER

7. 5. Effects of mixtures of endocrine disrupting chemicals – Thyroid disruption and behavioural effects in fish models

   Författare :Lina Birgersson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; endocrine disrupting chemicals; ecotoxicology; zebrafish; perch; locomotion; behaviour; thyroid disruption; EDC mixtures;

   Sammanfattning : Wildlife and humans are continuously exposed to thousands of man-made compounds, including chemicals that are able to act as endocrine disruptors (EDCs). These pollutants are able to affect vital processes including brain development, reproduction, metabolism and growth. LÄS MER