Sökning: "gamma-amino-butyric acid receptor A"

Hittade 4 avhandlingar innehållade orden gamma-amino-butyric acid receptor A.

  1. 1. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

    Författare :Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
    Nyckelord :Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

    Sammanfattning : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. LÄS MER

  3. 2. Conditional and non-conditional reward-related responses to alcohol. Nicotinic mechanisms

    Författare :Elin Löf; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ethanol; nicotine; ventral tegmental area; nucleus accumbens; dopamine; nicotinic acetylcholine receptor; gamma-amino-butyric acid receptor A; conditioned reinforcement; in vivo microdialysis; rat;

    Sammanfattning : The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine receptors (nAChRs) within this system appear important for the pharmacological actions of both alcohol and nicotine, which may explain the frequent co-abuse of these two drugs. LÄS MER

  4. 3. Neurotransmission in CNS regions involved in pain modulation : neurochemical effects of analgesic drugs and spinal cord stimulation in the spinal cord and midbrain periaqueductal grey of the rat

    Författare :Carl-Olav Stiller; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; dorsal horn; GABA; microdialysis; neurotensin; opioids; periaqueductal gray; sciatic nerve lesion; receptor binding; spinal cord stimulation; substance P.;

    Sammanfattning : The dorsal hom of the spinal cord and the midbrain penaqueductal grey matter (PAG) are important regions for pain modulation. In this thesis the effects of opioids and spinal cord stimulation (SCS) on the release of gamma-amino butyric acid (GABA), substance P (SP) and neurotensin (NT) were investigated in these regions of the rat by in vivo microdialysis. LÄS MER

  5. 4. Sensory neurons : stem cells and development

    Författare :Jens Hjerling-Leffler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sensory neuron; stem cells; development; boundary cap; GABA; TRPV 1; TRPA 1; TRPM8; calcium imaging; Foxs 1; SSEA-1; Schwann cells;

    Sammanfattning : The sensory nervous system is the only means we have of communicating with the surrounding world. The neurons responsible for the sensation of pain, touch, the ability to know the position of our limbs and part of maintenance of body posture are located in the dorsal root ganglia (DRG). LÄS MER