Sökning: "fused lasso"

Hittade 5 avhandlingar innehållade orden fused lasso.

1. 1. Comparative network analysis of human cancer: sparse graphical models with modular constraints and sample size correction

   Författare :José Sánchez; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Inverse covariance matrix; precision matrix; graphical models; high-dimension; low-sample; networks; sparsity; fused lasso; elastic net; cancer.; fused lasso;

   Sammanfattning : In the study of transcriptional data for different groups (e.g. cancer types) it's reasonable to assume that some dependencies between genes on a transcriptional or genetic variants level are common across groups. Also, that this property is preserved locally, thus defining a modular structure in the model networks. LÄS MER

3. 2. Network models with applications to genomic data: generalization, validation and uncertainty assessment

   Författare :José Sánchez; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inverse covariance matrix; precision matrix; graphical models; high-dimension; low-sample; networks; sparsity; fused lasso; elastic net; cancer; TCGA pan cancer analysis; online resource; discriminant analysis; classification; networks;

   Sammanfattning : The aim of this thesis is to provide a framework for the estimation and analysis of transcription networks in human cancer. The methods we develop are applied to data collected by The Cancer Genome Atlas (TCGA) and supporting simulations are based on derived models in order to reflect real data structure. LÄS MER

4. 3. Towards Precision Medicine: Exploiting Genetic Variation in Tumours by Inferring Multitype Gene Regulatory Networks

   Författare :Tobias Abenius; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; precision medicine; survival; cancer; gene regulatory networks; high-dimensional data; LASSO; Reproducible research; Generalized Pairwise Fused LASSO; Split Bregman;

   Sammanfattning : Precision medicine aims to customize treatment to a patient given measured genetic or other molecular data for diagnostics. In cancer, optimal medical treatment, depends on how far the disease has progressed, type and subtype of cancer and, the individual tumor’s circumstances. LÄS MER

5. 4. In Pursuit of Ideal Model Selection for High-Dimensional Linear Regression

   Författare :Arash Owrang; Magnus Jansson; Esa Ollila; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electrical Engineering; Elektro- och systemteknik;

   Sammanfattning : The fundamental importance of model specification has motivated researchers to study different aspects of this problem. One of which is the task of model selection from the set of available competing models. LÄS MER

7. 5. Experiment Design for Closed-loop System Identification with Applications in Model Predictive Control and Occupancy Estimation

   Författare :Afrooz Ebadat; Bo Wahlberg; Håkan Hjalmarsson; Erik Ydstie; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Experiment design; System identification; Model Predictive Control; Building automation; Occupancy estimation; Electrical Engineering; Elektro- och systemteknik;

   Sammanfattning : The objective of this thesis is to develop algorithms for application-oriented input design. This procedure takes the model application into account when designing experiments for system identification.This thesis is divided into two parts. LÄS MER