Sökning: "fibril aggregates"

Visar resultat 1 - 5 av 47 avhandlingar innehållade orden fibril aggregates.

  1. 1. Structural Elements in Native Celluloses

    Författare :Kristina Wickholm; KTH; []
    Nyckelord :cellulose I; accessible fibril surfaces; inaccessible fibril surfaces; para-crystalline cellulose; fibril aggregates; CP MAS 13C-NMR spectroscopy; spectral fitting; PCA; PLS;

    Sammanfattning : In this thesis, a schematic model for the structure ofaggregated cellulose I fibrils is proposed. The model consistsof a crystalline fibril core surrounded by less orderedcellulose forms. These cellulose forms are fibril surfacesaccessible to water, fibril surfaces inaccessible to water andpara-crystalline cellulose. LÄS MER

  3. 2. Molecular mechanisms in amyloid fibril formation

    Författare :Waltteri Hosia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis concerns investigations on molecular processes and interactions that lead to amyloid fibril formation. Pulmonary surfactant protein C (SP-C), and a synthetic analogue thereof, SP-C(Leu), have similar properties in terms of charge distribution, hydrophobicity and secondary structure, yet they differ in their aggregation propensities. LÄS MER

  4. 3. Amyloid β peptide: from monomer solubility to fibril structure

    Författare :Veronica Lattanzi; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer´s disease; Aβ solubility; small angle scattering; number of filaments; Aβ40; Aβ42 and Aβ42 S26Q ; fibril structure;

    Sammanfattning : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. LÄS MER

  5. 4. Roles of intermolecular interactions in amyloid fibril formation mechanisms

    Författare :Tony Werner; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; disulfide-bonds; Atox1; α-synuclein; Aggregation; protein interactions; Parkinson’s disease; β-parvalbumin; macromolecular crowding; osmolytes; Amyloid fibrils;

    Sammanfattning : Amyloid fibrils, a major pathological feature of several neurodegenerative disorders, are highly stable, insoluble aggregates of misfolded proteins. The formation of such aggregates involves a complex equilibrium between protein monomers, different on- and off-pathway transient oligomeric species, and amyloid fibrils. LÄS MER

  7. 5. Structural changes during cellulose composite processing

    Författare :Helena Halonen; Monica Ek; Tommy Iversen; Derek D. Gray; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; CP MAS 13C NMR; cellulose; fibril aggregation; biocomposite; compression moulding; supramolecular structure;

    Sammanfattning : Two approaches for creating a new all-cellulose composite material have been studied: the biosynthesis of compartmentalised bacterial cellulose fibril aggregates and the compression moulding of commercial chemical wood pulps processed with only water. The objective was to study the structural changes during processing and the complexity of relating the mechanical properties of the final biocomposites to the nanoscale structure was highlighted. LÄS MER