Sökning: "fenfluramine"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet fenfluramine.

1. 1. Serotonergic aspects on high consumption of alcohol in humans. Experimental and clinical studies

   Författare :Matts Eriksson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; alcohol-dependence; serotonin; SSRI; MAO-B; DRD2 A1 A2 alleles; fenfluramine; mood;

   Sammanfattning : In animal studies an association between alcohol intake and central serotonergic function has been demonstrated. There are also evidence for altered serotonergic neurotransmission in subgroups of alcohol-dependent subjects. LÄS MER

3. 2. Tryptophan-related Neurotransmission in the Brain: Disturbances Associated with Experimental Hepatic Encephalopathy

   Författare :Peter B F Bergqvist; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tetrodotoxin; serotonin; release; rat; quinolinic acid; potassium; chloroamphetamine; noradrenaline; neurotransmission; microdialysis; hepatic encephalopathy; fenfluramine; drug safety; dopamine; coma; citalopram; ammonia; calcium; brain; tryptophan; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : In the present study, L-tryptophan (TRP)-related disturbances in the brain in experimental hepatic encephalopathy (HE) were investigated. The endogenous NMDA-receptor agonist and L-TRP metabolite quinolinic acid (QUIN) has been suggested to be involved in the pathogenesis of HE. LÄS MER

4. 3. Assessment of dopamine and serotonin release in the non-human primate brain using PET

   Författare :Sjoerd J. Finnema; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The molecular imaging technique positron emission tomography (PET) allows for non-invasive examination of biochemical markers in the living brain. For over three decades PET studies have provided important insight into the relationship of monoaminergic neurotransmitter systems to brain functioning and psychiatric disorders. LÄS MER

5. 4. Development of novel 5-HT1B PET radioligands

   Författare :Anton Lindberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Positron emission tomography (PET) is a useful tool for studying the central nervous system (CNS) in living subjects. PET is a non-invasive imaging technique that can visualize biochemical process such as receptor-ligand interactions and has been utilized for several neurotransmitter systems including the serotoninergic system. LÄS MER

7. 5. PET studies on the mechanisms of action of antidepressant and antipsychotic drugs

   Författare :Kai-Chun Yang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Positron emission tomography (PET) is a non-invasive molecular imaging technique suitable for examination of neurochemical biomarkers in the living brain. Among these applications, PET studies are used to facilitate the development of novel psychotropic drugs. LÄS MER