Sökning: "extracellular space"

Visar resultat 1 - 5 av 82 avhandlingar innehållade orden extracellular space.

  1. 1. Water physiology in burn victims

    Författare :Joachim Zdolsek; Tøstolv Lund; Linköpings universitet; []
    Nyckelord :Total body water; Extracellular fluid; Burn; Bioelectrical impedance; Oedema; Extracellular matrix; MEDICINE; MEDICIN;

    Sammanfattning : Patients who sustain a burn injury of more than 20 - 30 % TBSA will, if untreated, develop burn shock within a couple of hours. Flcid is lost fi·om the vascular compartment due to suction from the interstitium of the wound and due to a generalised increase in vascular permeability. LÄS MER

  3. 2. Protein Engineering of Extracellular Superoxide Dismutase : Characterization of Binding to Heparin and Cellular Surfaces

    Författare :Ing-Marie Ahl; Lena Tibell; Bengt-Harald Jonsson; Steen Vang Petersen; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : Accumulating evidence indicates that oxygen free radicals are involved in many diseases and pathological conditions, such as aging, inflammation, reperfusion damage of ischemic tissue and various cardiovascular diseases. Extracellular superoxide dismutase (ECSOD) thus plays a major role in the maintenance of cells by providing protection against these toxic substances in the extracellular space. LÄS MER

  4. 3. Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin

    Författare :Snjolaug Sveinsdottir; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Intraventricular haemorrhage (IVH) is the most common brain lesion in preterm infants and is most commonly seen in the sickest children, with 15-20% of very preterm infants developing IVH. The mortality of infants with severe IVH is 20-50 % in the neonatal period and over 50 % of surviving infants develop post-haemorrhagic ventricular dilatation (PHVD) and 40-80 % develop severe neurological impairment, mainly cerebral palsy and mental retardation. LÄS MER

  5. 4. Migration of molecules in the brain : focus on the extracellular space and the cerebrospinal fluid

    Författare :Malin Höistad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Volume transmission; rat; diffusion; striatum; dual-probe microdialysis; delivery; recovery; clearance; uptake; dopamine; metabolism; radiotracer; mannitol; cisterna magna; opioids; peptides; betaendorphin; mu-opioid receptors; mismatch; TH; DBH; immunohistochemistry; fear.;

    Sammanfattning : Three different molecules and three different experimental models were used to study the migration of molecules in the rat brain: a neurotransmitter- dopamine, an extracellular market- mannitol, and a neuropeptide beta-endorphin. Two models in vivo were used to study the diffusion and migration of molecules: dual-probe rnicrodialysis in the striatum, and direct intrastriatal microinjections followed by cerebrospinal fluid sampling from the cisterna magna. LÄS MER

  7. 5. Regulation of Renal Hyaluronan in Water Handling : Studies in vivo and in vitro

    Författare :Sara Stridh; Peter Hansell; Mats Rundgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; water balance; fluid handling; diabetes; nephropathy; ACE fetopathy; reabsorption; hyaluronic acid; glycosaminoglycan; GAG; extracellular matrix; mTOR; rapamycin; streptozotocin;

    Sammanfattning : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. LÄS MER