Sökning: "expression quantitative trait loci"
Visar resultat 1 - 5 av 28 avhandlingar innehållade orden expression quantitative trait loci.
1. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects
Sammanfattning : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. LÄS MER
2. QTL Analysis in the Pig : From the Identification of Quantitative Trait Loci to the Understanding of Molecular Mechanisms
Sammanfattning : Domestic pigs have become very different form the wild ancestors they originate from. Selection for muscle growth and meat quality has made the pig a good model for genetic studies of muscle development.The first part of this thesis presents a genome-wide scan for quantitative trait loci (QTL) in a cross between Landrace and Hampshire pigs. LÄS MER
3. Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases
Sammanfattning : Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. LÄS MER
4. Identification and characterization of DNA sequence variants associated with multiple myeloma
Sammanfattning : Multiple myeloma (MM) is the second most common hematologic malignancy. The disease is characterized by an uncontrolled growth of malignant plasma cells in the bone marrow, producing a monoclonal immunoglobulin (“M protein”) that can be detected in peripheral blood. LÄS MER
5. Gene Expression in the Brains of Two Lines of Chicken Divergently Selected for High and Low Body Weight
Sammanfattning : Artificial divergent selection of chickens for high and low body weight at 8 weeks of age has produced two lines: the high (HWS) and low (LWS) body weight chicken lines. In addition to the difference in body weight, the lines show extreme differences in feeding behaviour and body composition. LÄS MER