Sökning: "epoxide-opening"

Hittade 3 avhandlingar innehållade ordet epoxide-opening.

  1. 1. Synthesis of O-linked Carbasugar Analogues of Galactofuranosides and N-linked Neodisaccharides

    Författare :Jens Frigell; Ian Cumpstey; George Fleet; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbasugar; galactofuranose; mycobacterium; tuberculosis; ring-closing metathesis; GlfT2; galactan; epoxide-opening; pseudodisaccharide; etherification; regioselective; carbohydrate; carbocycles; glycomimetics; glucosidase; neodisaccharides; Mitsunobu; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : In this thesis, carbohydrate mimicry is investigated through the syntheses of carbohydrate analogues and evaluation of their inhibitory effects on carbohydrate-processing enzymes. Galactofuranosides are interesting structures because they are common motifs in pathogenic microorganisms but not found in mammals. M. LÄS MER

  3. 2. Quantum chemical studies of epoxide-transforming enzymes

    Författare :Kathrin H. Hopmann; Hans Ågren; Margareta Blomberg; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : Density functional theory is employed to study the reaction mechanisms of different epoxide-transforming enzymes. Calculations are based on quantum chemical active site models, which are build from X-ray crystal structures. The models are used to study conversion of various epoxides into their corresponding diols or substituted alcohols. LÄS MER

  4. 3. Nitrile Hydratases and Epoxide-Transforming Enzymes : Quantum Chemical Modeling of Reaction Mechanisms and Selectivities

    Författare :Kathrin Hopmann; Fahmi Himo; Nigel G. Richards; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : Quantum chemical studies of enzymatic reactions are able to provide detailed insight into mechanisms and catalytic strategies. The energetic feasibility of proposed mechanisms can be established, and new possible reaction pathways can be put forward. LÄS MER