Sökning: "endothelium-derived relaxation factor"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden endothelium-derived relaxation factor.
1. Endothelial function during ischemia-reperfusion and effects of inhalation of nitric oxide
Sammanfattning : The vascular endothelium is an important regulatory organ in circulatory physiology and plays a central role in the response to acute inflammation and ischemia/reperfusion. Activation and dysfunction of the pulmonary vascular endothelium are closely related to clinical findings of pulmonary dysfunction. LÄS MER
2. Regulation of vascular tone in myometrial resistance arteries in normal pregnancy and preeclampsia
Sammanfattning : Background: Normal pregnancy is characterized by the occurrence of substantial vasodilatation. Pressure responsiveness and vascular reactivity to administered vasoconstrictors undergo considerable attenuation. These circulatory changes are essential to maintain adequate oxygen and nutrient delivery to the placenta and thus to the fetus. LÄS MER
3. Vasodilator actions of EDHF and anandamide
Sammanfattning : Vasodilator responses to endothelium-derived hyperpolarizing factor (EDHF) and anandamide in isolated arteries were investigated. A combination of the potassium channel blockers charybdotoxin and apamin inhibits EDHF-mediated relaxations. LÄS MER
4. A study of potassium channel activation as a pharmacological principle for vasodilation of cerebral blood vessels
Sammanfattning : Increasing [K+]o is intimately coupled to progressive ischemia and reduced CBF. In isolated cerebral and mesenteric arteries, it was found that significant differences in the vascular responses to [K+]o exist. Among the species studied, human cerebral arteries were the most sensitive artery to increasing [K+]o. LÄS MER
5. New insights into the control of small artery function in human pregnancy and estrogen receptor beta knockout mice
Sammanfattning : Background: Available data clearly indicates functional and morphological differences between small and large arteries, and observations from studies on large arteries may not be applicable to understand the physiology of small arteries (~200-300mum) that actively participate in the regulation of peripheral vascular resistance, blood pressure and flow to target organs. These events confer cardiovascular adaptation to normal pregnancy (NP), however they are disturbed in preeclampsia (PE) and in estrogen receptor beta knockout (ERbetaKO) mice at a certain age. LÄS MER