Sökning: "endothelial dysfunction and left ventricular dysfunction"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden endothelial dysfunction and left ventricular dysfunction.

1. 1. The Kidney in Different Stages of the Cardiovascular Continuum

   Författare :Elisabet Nerpin; Johan Ärnlöv; Erik Ingelsson; Ulf Riserus; Jan Östergren; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidemiology; chronic kidney disease; cystatin C; glomerular filtration rate; albuminuria; euglycemic hyperinsulinemic clamp; insulin sensitivity; inflammation; oxidative stress; endothelial dysfunction and left ventricular dysfunction; Medicin; Medicine; Nedsatt njurfunktion; insulinresistens; oxidativ stress och utvecklingen av hjärt-kärlsjukdomar;

   Sammanfattning : Patients with chronic kidney disease are at higher risk of developing cardiovascular disease. The complex, interaction between the kidney and the cardiovascular system is incompletely understood, particularly at the early stages of the cardiovascular continuum. LÄS MER

3. 2. Vardenafil and methylarginines in pulmonary hypertension

   Författare :Anna Sandqvist; Gerhard Wikström; Jörn Schneede; Amrita Ahluwalia; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vardenafil; pulmonary hypertension; pharmacokinetics; haemodynamics; right heart catheterization; adenosine; dimethylarginines; phosphodiesterase type 5 inhibitors; endothelin receptor antagonists; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Background: Pulmonary hypertension (PH) is a rare condition characterized by endothelial dysfunction and vascular remodelling, leading to increased pulmonary vascular resistance (PVR) and right ventricular heart failure. Endothelial dysfunction is associated with an imbalance between vasoconstrictor compounds, such as endothelin and thromboxane A2, and vasodilator compounds, such as prostacyclin and nitric oxide (NO). LÄS MER

4. 3. The role of fibroblast growth factor-23 in chronic kidney disease-mineral and bone disorder

   Författare :Majd A. I. Mirza; Tobias Larsson; Tilman Drüeke; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FGF23; FGF-23; CKD; CKD-MBD; cardiovascular disease; vascular function; atherosclerosis; hypertrophy; LVMI; LVH; fractures; bone; fat mass; obesity; apolipoproteins; cholesterol; lipids; Kidney diseases; Njursjukdomar; Cardiovascular medicine; Kardiovaskulär medicin; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Fibroblast growth factor-23 (FGF23) was initially identified as the causative factor of autosomal dominant hypophosphatemic rickets. Further studies confirmed that FGF23 is predominantly expressed in the osteocytes and osteoblasts of bone and that circulating FGF23 acts on the kidney to inhibit renal phosphate reabsorption and 1,25(OH)2D3 hydroxylation. LÄS MER

5. 4. Noninvasive Evaluation of Myocardial Ischemia and Left Ventricular Function

   Författare :Eva Maret; Jan Ohlsson; Eva Nylander; Anders Waldenström; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The general aim of this thesis was, following the path of the ischemic cascade, to evaluate the feasibility of some new non-invasive techniques for the detection of myocardial ischemia, the extent of infarcted myocardium, and for the quantification of systolic left ventricular function.Reduced longitudinal myocardial velocity and displacement may be early signs of ischemia. LÄS MER

7. 5. Angiotensin-converting enzyme in cardiovascular function and dysfunction

   Författare :Liza Ljungberg; Toste Länne; Karin Persson; Urban Alehagen; Thomas Kahan; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system, converting angiotensin I to the vasoactive peptide angiotensin II, and degrading bradykinin. Angiotensin II is a multifunctional peptide, acting on a number of different tissues. LÄS MER