Sökning: "endocrine disruptors"

Visar resultat 6 - 10 av 18 avhandlingar innehållade orden endocrine disruptors.

1. 6. Fishy behavior : persistent effects of early-life exposure to 17α-ethinylestradiol

   Författare :Kristina Volkova; Inger Porsch Hällström; Svante Winberg; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endocrine disruptors; anxiety; stress behavior; transgenerational effects; 17α-ethinylestradiol; developmental exposure; social behavior; fish; Biology; Biologi;

   Sammanfattning : The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting chemical (EDC) of concern due to its persistent nature and widespread presence in the aquatic environment. In mammals, effects of developmental EDC exposure on reproduction and behavior not only persist to adulthood after discontinued exposure, but are also inherited by several consecutive unexposed generations. LÄS MER

3. 7. Computational methods for assessing chemical risk : focusing on toxicokinetic modelling in zebrafish (danio rerio)

   Författare :Ioana C. Chelcea; Patrik L. Andersson; Timo Hamers; Jessica Legradi; Stefan Örn; Carolina Vogs; Nynke Kramer; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PBTK; Toxicokinetics; Endocrine disruptors; bisphenols; zebrafish; embryo; Toxicology; toxikologi;

   Sammanfattning : New chemicals are constantly produced and large data gaps exist on hazards of currently used industrial chemicals, stressing the need for rapid, ethically sound and cost-efficient hazard assessment methods. Traditional methods for effect assessment based on animal testing, do not meet these requirements and thus the toxicology field has been moving towards the development of new approach methodologies which include in vitro approaches but also computational methods. LÄS MER

4. 8. Fish on drugs : behaviour modifying contaminants in aquatic ecosystems

   Författare :Annelie Lagesson; Jonatan Klaminder; Tomas Brodin; Kathryn Arnold; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aquatic ecosystems; Behavioural effects; Ecotoxicology; Endocrine disruptors; Pharmaceuticals; Interaction effects; ekotoxikologi; Ecotoxicology;

   Sammanfattning : Contamination of surface waters is a worldwide problem. One group of emerging contaminants that reach aquatic ecosystems via sewage treatment plant effluents and agricultural run-offs is pharmaceuticals. LÄS MER

5. 9. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis

   Författare :Vichit Supornsilchai; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Endocrine disrupting chemicals EDCs ; steroidogenesis; Leydig cells; adrenocortical cells; steroidogenic acute regulatory protein StAR ; steroidogenic enzymes;

   Sammanfattning : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. LÄS MER

7. 10. Zebrafish as a model to study the neuroendocrine system and toxicity of endocrine disruptors

   Författare :Gayathri Chandrasekar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Zebrafish is a popular vertebrate model system to study development and perform genetic analysis. It offers numerous advantages such as small size, short generation time, high fecundity, rapid and ex utero development of embryos and optically transparent embryos. LÄS MER