Sökning: "elastase inhibitors"

Visar resultat 6 - 10 av 16 avhandlingar innehållade orden elastase inhibitors.

  1. 6. Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design

    Författare :Anton Poliakov; Helena Danielson; Boris Turk; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; serine protease; inhibitor; slow-binding; protein purification; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. LÄS MER

  3. 7. Experimental and Clinical Studies of SLPI, with Special Reference to IgE-Mediated Allergic Reactions

    Författare :Ulla Westin; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ hybridisation; immunohistochemistry; allergic rhinitis; atopic subjects; IgE-mediated histamine release; mast cell proteases; plasma protease inhibitors; SLPI; human leukocyte proteases; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : In this study we demonstrated the production of SLPI (Secretory Leukocyte Protease Inhibitor) in serous glands in the nasal mucosa. We have shown that the pattern of the expression of mRNA corresponds to the encoded protein. The encoded protein was detected by immunohistochemical methods and mRNA was discovered by in situ hybridisation. LÄS MER

  4. 8. Tobacco smoking, vascular reaction and neutrophil activity in periodontal health and disease

    Författare :Lena Persson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tobacco smoking has considerable negative effects on periodontal health. The mechanisms behind these effects may be related to the inflammatory response. In this thesis, the main aim was to study the influence of tobacco smoking on the inflammatory response in periodontal health and disease. LÄS MER

  5. 9. Significance of intraluminal thrombus in abdominal aortic aneurysm

    Författare :Maggie Folkesson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Most AAAs contain an intraluminal thrombus (ILT) and the volume of the ILT correlates with aneurysm size. The thrombus-covered wall is a common site for rupture after bleeding into the ILT. The hypothesis for this thesis was generated when Kazi et al discovered differences in AAA wall between ILT covered and ILT free aortic wall. LÄS MER

  7. 10. The role of red blood cells in inflammation and remodeling

    Författare :Karin Fredriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Red blood cells; fibroblast; inflammation; remodeling; fibrosis;

    Sammanfattning : Besides being carriers of oxygen and carbon dioxide, red blood cells (RBCs) also have a scavenger function, binding inflammatory mediators to surface receptors. Animal and experimental models have suggested a role for RBCs in inflammatory and fibrotic responses and patients with idiopathic pulmonary hemosiderosis, a disease characterized by lung hemorrhage, frequently develop fibrosis. LÄS MER