Sökning: "elastase inhibitors"

Visar resultat 11 - 15 av 16 avhandlingar innehållade orden elastase inhibitors.

1. 11. Intermediate State Stabilisation in Enzyme Catalysis Structural studies of two serine proteases and a photosynthetic reaction centre

   Författare :Gergely Katona; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; photosynthetic reaction centre; X-ray crystallography; structural mechanism; enzyme kinetics; serine protease; enzyme intermediate; enzyme catalysis;

   Sammanfattning : Enzymes play a key role in every organisms life. They catalyse chemical reactions and may also respond to external stimulus. The reoccurring theme of this thesis is how biologically relevant information can be gleaned from X-ray structures of the enzymes. LÄS MER

3. 12. Targeting bacterial infections by using immunomodulatory host defence peptides and proteins

   Författare :Martina Kalle; Lund Dermatologi och venereologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host dfence peptides; Sepsis; Immunomodulation; Heparin cofactor II;

   Sammanfattning : Bacterial infections and sepsis are amongst the leading causes of death worldwide. Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment of sepsis remains challenging. LÄS MER

4. 13. Alpha1-Antitrypsin: New insights into the biological role in vitro and in vivo

   Författare :Izabela Nita; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Alpha1-Antitrypsin (AAT), an acute-phase glycoprotein produced predominantly in the liver by hepatocytes, but also by macrophages, pulmonary alveolar cells and intestinal epithelial cells, is a member of the SERPIN superfamily (SERine Protease INhibitors), and is one of the major inhibitors of neutrophil elastase in human plasma. Although AAT plays a critical role in regulating inflammation by inhibiting neutrophil serine proteases, recent studies suggest that AAT exhibits much broader anti-inflammatory activity. LÄS MER

5. 14. Studies on vasoactivity of fibrin(ogen) derived peptides

   Författare :Katarina Saldeen; Asrar Malik; Linköpings universitet; []
   Nyckelord :Fibrin ogen derived peptides; vasoactivity; prostacyclin; nitric oxide; angiotensin converting enzyme; MEDICINE; MEDICIN;

   Sammanfattning : Fibrin accumulation is a common fmding in many pathological conditions, such as in inflammatory processes, e.g. in the lungs in pneumonia or pulmonary insufficiency after sepsis. During lysis of the fibrin by plasmin or leukocyte elastase, peptides are released that may contribute to the pathophysiological changes. LÄS MER

7. 15. Interleukin-17 in non-allergic airway inflammation

   Författare :Martti Laan; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-17; airway inflammation; bronchial epithelial cells; neutrophils; T-lymphocytes; IL-8; IL-6; MAP kinases.;

   Sammanfattning : Chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchial asthma and cystic fibrosis are common clinical disorders all characterized by airway neutrophilia. By releasing proteolytic enzymes and free oxygen radicals, neutrophils can contribute to the main features of these diseases such as airway obstruction, hypersecretion and remodelling. LÄS MER