Sökning: "elastase inhibitors"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden elastase inhibitors.

1. 1. Characterization of conjugated protease inhibitors

   Författare :Erika Billinger; Gunnar Johansson; Boris Turk; Uppsala universitet; []
   Nyckelord :Serine protease inhibitors; conjugation; immobilization; leupeptin analogues; potato serine protease inhibitor; soluble carriers; inorganic carriers.; Biokemi; Biochemistry;

   Sammanfattning : The overall theme of this thesis is a step by step approach for the design and characterization of conjugated protease inhibitors. This involves both a new assay method for protease activity and protease inhibition (paper I), a study of the stoichiometry for protease inhibitor interaction (paper II), design of inhibitory peptides (paper IV) and the construction of inhibitor conjugates (paper III & IV). LÄS MER

3. 2. Secretory Leukocyte Protease Inhibitor (SLPI) in the gastrointestinal tract in man

   Författare :Max Nyström; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; elastase inhibitors; human leukocyt proteases; Plasma protease inhibitors; NGAL; Ulcerative colitis; Antileukoprotease; IBD; traumatologi; ortopedi; traumatology; orthopaedics; Immunology; serology; transplantation; Immunologi; serologi; Kirurgi;

   Sammanfattning : Secretory leukocyte protease inhibitor is a 11.7 kDa acid stable serine protease inhibitor. SLPI has been shown to be the dominant protease inhibitor in bronchial secretions and has been used in treatment of pulmonary emphysema. LÄS MER

4. 3. Serine protease inhibitors in the upper and lower airways

   Författare :Camilla Hollander; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; auditive system and speech; Neutrophils; audiology; Otorhinolaryngology; Medicin människa och djur ; AAT; Medicine human and vertebrates ; SLPI; cytokines chemokines; anti-proteases; audiologi; hörsel- och talorganen; Airway inflammation; Otorinolaryngologi;

   Sammanfattning : Proteases and their inhibitors are implicated in the physiology and pathology of the airways. Protease inhibitors include those produced locally, such as secretory leukocyte protease inhibitor (SLPI), and those produced mainly by the liver that can reach the airways via passive diffusion, such as alpha1-antitrypsin (AAT). LÄS MER

5. 4. Alpha 1-antitrypsin: A Role in Cancer Progression

   Författare :Inga Zelvyté; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; invasion; neutrophils; cancer cell; Alpha1- antitrypsin; proteinase inhibitors;

   Sammanfattning : Alpha1-antitrypsin (AAT), a circulating single-chain glycoprotein is the most abundant serine proteinase inhibitor in human plasma. AAT is an acute phase protein, its levels increase rapidly to concentrations exceeding 50mM in response to inflammation, infection and malignant diseases. LÄS MER

7. 5. Conformational Entropy and Protein Flexibility in Drug Design Studied by NMR Spectroscopy

   Författare :Carl Diehl; Biofysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MMP-12; Galectin-3; confomational entropy; order parameters; ITC; Protein dynamics; isothermal titration calorimetry; macrophage elastase; nuclear magnetic resonance; NMR;

   Sammanfattning : Proteins are complex molecules, present in all of the vital functions of life. The function of a protein is regulated by interactions between protein and other molecules. Drug design in pharmaceutical science aims to regulate the function of a protein by the design of synthesized molecules that binds to a protein with high affinity. LÄS MER