Sökning: "early-life"

Visar resultat 1 - 5 av 223 avhandlingar innehållade ordet early-life.

  1. 1. Lin28b regulation of early-life B lymphopoiesis. A model system to study how self-reactive B cells develop in early life

    Författare :Hugo Åkerstrand; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lin28b; Developmental Immunology; B-1 B cells; Self-reactivity; B cell development; Early-life;

    Sammanfattning : .... LÄS MER

  3. 2. Early life experiences and alcohol use in youth : An emerging role of the Vesicular Glutamate Transporters

    Författare :Maria Vrettou; Erika Comasco; Ingrid Nylander; Kent W. Nilsson; Åsa Wallén-Mackenzie; Roberto Ciccocioppo; Uppsala universitet; []
    Nyckelord :alcohol; early-life stress; brain; early adulthood; expression; DNA methylation; glutamate; Vesicular Glutamate Transporters;

    Sammanfattning : Initiation of alcohol consumption usually takes place during adolescence, a period characterized by a plethora of physical and emotional changes. Towards early adulthood, hazardous drinking patterns can emerge and potentially lead to the development of Alcohol Use Disorder (AUD). LÄS MER

  4. 3. Adolescent behavior : Links to early-life stress and alcohol in male and female rats

    Författare :Stina Lundberg; Erika Roman; Ingrid Nylander; Heidi MB Lesscher; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adolescence; alcohol exposure; behavior; corticosterone; dynorphin; early life; endogenous opioid peptides; Met-enkephalin-Arg6Phe7 MEAP ; individual differences; multivariate concentric square field MCSF ; phenotyping; radioimmunoassay; selective breeding for alcohol consumption; voluntary alcohol intake; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Adolescence is an important developmental phase with large changes in behavior, physiology and neurobiology, which transform an individual from immature child to independent adult. Due to these changes, adolescence is a sensitive period for exposure to environmental factors such as stress and drug exposure; it is also a common age of onset for alcohol consumption as well as several psychiatric disorders. LÄS MER

  5. 4. Early life origins of health and well-being in modern Sweden

    Författare :Serhiy Dekhtyar; Ekonomisk-historiska institutionen; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Economic history; demography; health; developmental origins; early life hypothesis; Barker hypothesis; life course; intergenerational mobility; entry into motherhood; childhood cognitive ability; dementia; 20th century Sweden; register data;

    Sammanfattning : The aim of this thesis is to examine the role of early life environments for a variety of individual-level health and socioeconomic outcomes in contemporary Sweden. Ever-expanding human lifespans have contributed to the emergence of novel socio-health phenomena confronting contemporary Swedish society. LÄS MER

  7. 5. Scarred for Life. How conditions in early life affect socioeconomic status, reproduction and mortality in Southern Sweden, 1813-1968

    Författare :Luciana Quaranta; Centrum för ekonomisk demografi; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Early life; selection and scarring; diet and disease; life course; historical demography; southern Sweden; 19th and 20th century;

    Sammanfattning : The aim of this doctoral thesis is to contribute to the debate on the importance of diet and disease in explaining the mortality decline and the general literature of the long-term effects of early life conditions. Using individual-level data from Southern Sweden for 1813 to 1968, this work measures the impacts of grain prices during the foetal stage and infant mortality rates during the year of birth on mortality over the full life course, as well as on female socioeconomic status attainment and reproductive health. LÄS MER