Sökning: "dual RNA-seq"

Hittade 4 avhandlingar innehållade orden dual RNA-seq.

  1. 1. Evolutionary genomics of host-microbe interactions

    Författare :Elin Videvall; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; host; microbiota; avian malaria; ostrich; parasite; dual RNA-seq;

    Sammanfattning : The microbes living inside hosts have highly important consequences for host health and fitness. From the host’s perspective, some microbes exhibit mutualistic tendencies, others parasitic, and some commensal, but this is context-dependent and opportunistic lifestyles are widespread in nature. LÄS MER

  3. 2. Host-parasite interactions in space and time

    Författare :Franziska Hildebrandt; Johan Ankarklev; Volker T. Heussler; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Malaria; liver-stage infection; Toxoplasma; host-parasite interactions; spatial transcriptomics; single-cell omics; single-cell Dual-seq; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Unicellular parasites of the apicomplexan phylum have a considerable effect on global health and agriculture. Two prominent examples of this phylum include malaria causing parasites of the Plasmodium genus and the widely prevalent parasite Toxoplasma gondii. LÄS MER

  4. 3. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine

    Författare :Patrick Nylund; Helena Jernberg Wiklund; Antonia Kalushkova Nair; Fredrik Öberg; Toril Holien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; PRC2; lncRNA; metabolomics; miRNA.;

    Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER

  5. 4. Mechanisms acting on Hedgehog-GLI pathway and their therapeutic potential

    Författare :Ani Azatyan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hedgehog signaling is crucial for diverse aspects of animal development, essential in regulating many cellular processes and is largely implicated in various forms of human cancer. However, many aspects of Hedgehog signaling are not completely understood. LÄS MER