Sökning: "cyclins"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet cyclins.

  1. 1. Characterization of Male Breast Cancer : From Molecule to Clinical Outcome

    Författare :Cecilia Nilsson; Marie-Louise Fjällskog; Leif Bergkvist; Thomas Hatschek; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; male breast cancer; immunohistochemistry; prognostic; cyclins; gene expression; genomic profiling; Oncology; Onkologi; Oncology; Onkologi;

    Sammanfattning : The aim of this thesis was to investigate different aspects of male breast cancer (MBC), and to compare these with findings in female breast cancer (FBC). In paper I, a population–based study was performed to investigate possible differences in treatment and outcome between MBC and FBC patients. LÄS MER

  3. 2. Cyclins on the move : a time and a place for cyclin A2 and cyclin B1 in the human cell cycle

    Författare :Helena Silva Cascales; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ultimate aim of the cell cycle is to create an identical daughter cell. Therefore, correct progression through the different phases of the cell cycle is crucial to ensure faithful cell division. LÄS MER

  4. 3. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

    Författare :Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

    Sammanfattning : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. LÄS MER

  5. 4. Tumor progression in melanocytic lesions : biological and diagnostic implications

    Författare :Lena Kanter-Lewensohn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :melanocytic tumors; MIB-1; Bcl-2; IGF-1R. p27; cyclins; cdks and Tamoxifen;

    Sammanfattning : Cutaneous malignant melanoma has an annual incidence of 5% in Sweden, with about 1500 cases diagnosed yearly. In routine histopathology there are diagnostic difficulties in the analysis of pigmented lesions. LÄS MER

  7. 5. G1-phase cyclin expression in neoplastic B cells

    Författare :Richard Scuderi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; G1 phase; cyclin D; cyclin E; EBV; Burkitt s; B-ALL; B-CLL; apoptosis;

    Sammanfattning : By virtue of the role of G1-phase cyclin proteins as regulators of differentiation, proliferation, and apoptosis, their improper expression can lead to altered cellular homeostasis and tumor formation. Cyclins provide the regulatory partner for cyclin-cdk complexes whose enzymatic activity drives cell cycle progression. LÄS MER