Sökning: "cross-species"

Visar resultat 11 - 15 av 22 avhandlingar innehållade ordet cross-species.

  1. 11. Molecular and cellular characterization of midbrain dopaminergic neuron development

    Författare :Daniel Gyllborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic medicine. Parkinson’s disease (PD) is a debilitating neurological disorder that to date has no cure or established cause. LÄS MER

  3. 12. Too close for comfort : The role of Contact-Dependent growth Inhibition (CDI) in interbacterial competition and cooperation

    Författare :Marcus Wäneskog; Sanna Koskiniemi; Paul Rainey; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bacterial interactions; cell-cell binding; contact-dependent growth inhibition; CDI; CdiB; CdiA; CdiI; outer-membrane receptor; BamA; OmpC; OmpF; extracellular toxin delivery; Toxin-Antitoxin; TA-system; persister cells; stress tolerance; stress response; rpoS; rssB; quorum sensing; multicellular behavior; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Contact-Dependent growth inhibition (CDI) was discovered in 2005 in the E. coli isolate EC93. Since then our knowledge of CDI systems and their impact on bacterial communities have increased exponentially. LÄS MER

  4. 13. Exploiting Drosophila as a model system for studying anaplastic lymphoma kinase in vivo

    Författare :Therese Eriksson; Ruth Palmer; Stefan Thor; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; Receptor tyrosine kinase; Jeb; neuroblastoma; actin polymerization; Wasp; Scar; Vrp1; Arp2 3; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and an oncogene associated with several human diseases, but its normal function in humans and other vertebrates is unclear. Drosophila melanogaster has an ALK homolog, demonstrating that the RTK has been conserved throughout evolution. LÄS MER

  5. 14. In silico prediction of CIS-regulatory elements

    Författare :Albin Sandelin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Transcriptional regulation; transcription factor binding sites; phylogenetic footprinting; pattern finding; pattern comparison;

    Sammanfattning : As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of genes is laborious and expensive, but can be substantially accelerated with the use of computational predictions. LÄS MER

  7. 15. Innate and acquired immunity to Leishmania in humans : the role of the host versus the parasite

    Författare :Kerima Maasho; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leishmania are intracellular protozoan parasites of macrophages which induce chronic diseases in man. The study of this parasite has been instrumental in elucidating many facets of the immune system. Our study set out to understand the immune regulatory mechanisms involved in resistance and susceptibility. LÄS MER