Sökning: "cre-loxP"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet cre-loxP.

  1. 1. Conditional targeting of the PDGF-B gene

    Författare :Maria Enge; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene targeting; Cre loxP; PDGF; pericytes; diabetic retinopathy; brain injury; neurons;

    Sammanfattning : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. LÄS MER

  3. 2. Effects of PDGF-B gene inactivation in endothelial cell

    Författare :Mattias Bjarnegård; Göteborgs universitet; []
    Nyckelord :gene targeting; Cre loxP; PDGF; pericyte; mouse; microangiopathy;

    Sammanfattning : Platelet-derived growth factor-B (PDGF-B) is expressed by endothelial cells, neurons, macrophages and platelets. The relative importance of these cellular PDGF-B sources in vivo has been addressed by the creation of a conditional PDGF-B allele, which in the presence of a specific recombinase can be silenced in different tissues. LÄS MER

  4. 3. The role of TGF-§ in hematopoiesis

    Författare :Jonas Larsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transforming growth factor-§; Cre loxP system; receptor; knockout; embryogenesis; angiogenesis; hematopoiesis; hematopoietic stem cell; inflammation; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Transforming growth factor-§ (TGF-§) is a potent, multifunctional growth factor affecting virtually all cell types, regulating critical physiological processes like immune response, wound healing, angiogenesis, and tumor development. A large number of studies in vitro have also implicated a critical role of TGF-§ in regulating hematopoiesis by inhibiting proliferation of hematopoietic stem cells (HSCs). LÄS MER

  5. 4. The significance of blood vessels in organogenesis and cadherins in exploratory behaviour

    Författare :Josefina Edsbagge; Göteborgs universitet; []
    Nyckelord :pancreas; sphingosine-1-phosphate; endothelium; epithelial-to-mesenchymal interactions; ; Cre loxP-system; cadherins; rearing;

    Sammanfattning : Organogenesis of epithelial organs requires interaction between epithelial andmesenchymal tissues. In pancreas development three different mesenchymal derivedstructures, the notochord, the endothelial cells and the splanchnic mesenchyme inducespecification, growth and further differentiation of the pancreatic epithelium. LÄS MER

  7. 5. Life without mitochondrial DNA : studies of transgenic mice

    Författare :Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

    Sammanfattning : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. LÄS MER