Sökning: "cox-1"

Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet cox-1.

  1. 1. Prostaglandin E2 in Brain-mediated Illness Responses

    Författare :Louise Elander; Anders Blomqvist; Marianne Schultzberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin e2; PGE2; cox-1; cox-2; mPGES-1; fever; anorexia; food intake; HPA-axis; EP-receptor; LPS; IL-1; IL-6; MEDICINE; MEDICIN; Neurobiology; Neurobiologi;

    Sammanfattning : We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. LÄS MER

  3. 2. Computational methods for calculating binding free energies of ligands in COX-1

    Författare :Yasmin Shamsudin Khan; Johan Åqvist; Jens Carlsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 3. Non-Steroidal Anti-Inflammatory Drugs in Cyclooxygenases 1 and 2 : Binding modes and mechanisms from computational methods and free energy calculations

    Författare :Yasmin Shamsudin Khan; Johan Åqvist; Hugo Gutiérrez de Terán; Xavier Barril; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular dynamics simulations; binding free energy; molecular docking; cyclooxygenase; non-steroidal anti-inflammatory drugs; free energy perturbation; potentials of mean force;

    Sammanfattning : Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of drugs. They target the cyclooxygenases (COX) 1 and 2 to reduce the physiological responses of pain, fever, and inflammation. Due to their role in inducing angiogenesis, COX proteins have also been identified as targets in cancer therapies. LÄS MER

  5. 4. Bioassay Development for Identification of Cyclooxygenase-2 Inhibitors of Natural Origin

    Författare :Therese Ringbom; Angelika Vollmar; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi; Pharmacognosy; farmakognosi;

    Sammanfattning : To examine cyclooxygenase-2 (COX-2) inhibitory effects of natural compounds and structurally related compounds, a radiochemical assay for measuring inhibition of COX-2 and COX-1 catalysed prostaglandin biosynthesis was optimised. That process resulted in the development of a reliable assay for finding COX-2 inhibitors in plants, and for investigating plant constituents pertaining to the inhibition of COX-2 and COX-1. LÄS MER

  7. 5. mPGES-1 and the PGE2 pathway in arthritis

    Författare :Marie Westman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Prostaglandins; mPGES-1; PGES2; cyclooxygenase; rheumatoid arthritis; collagen induced arthritis; antirheumatic treatments; inflammation; synovial tissue; steroids; TNF blockade;

    Sammanfattning : Prostaglandins are a group of lipid mediators derived from essential fatty acids that act on cells in close proximity of their synthesis. Prostaglandins are produced in a cell specific manner by a variety of cells in response to physiological or pathological stimulation. LÄS MER