Sökning: "complement C5"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden complement C5.

  1. 1. Complement-dependent defence against bacterial infection. Studies in C2 deficiency

    Författare :Barbro Selander; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody responses; polysaccharide antigens; vaccination; mannan-binding lectin MBL ; complement; C2 deficiency; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : The complement system is critically involved in defence against bacterial infection. C2 deficiency is, apart from mannan-binding lectin (MBL) deficiency, the most common homozygous complement deficiency among Caucasians. LÄS MER

  3. 2. Glial cell responses, complement and clusterin expression after lesions in central or peripheral nervous system

    Författare :Li Liu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Glia; Complement; Clusterin; Proliferation; Peripheral nerve injury; Spinal cord injury; Rhizotomy; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : The present Thesis examines the expression and role of complement and the complement regulator clusterin after central or peripheral axon injury in relation to the responses of non-neuronal cells. Following peripheral sensory nerve injury, complement was expressed in the spinal cord and brain stem in association with reactive microglia, which also appeared to be a local source of complement. LÄS MER

  4. 3. Complement evasion strategies of human pathogens - the evolutionary arms race

    Författare :Monika Jusko; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complement system; pathogen; periodontitis; proteases; immune escape;

    Sammanfattning : Although the complement system, a pivotal component of innate immunty, is centrally involved in host defense against pathogens, its overactivation or deregulation may excessively amplify inflammation and contribute to immunopathology. Periodontitis, an oral infection-driven chronic inflammatory disease, has been linked with complement disruption by periodontal bacteria, resulting in inflammation and pathogenesis. LÄS MER

  5. 4. The Role of Fc Gamma Receptors in Experimental Arthritis

    Författare :Maria Andrén; Sandra Kleinau; Birgitta Heyman; Roland Jonsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Rheumatoid arthritis; Antibodies; Fc receptors; Complement; Transgenic Knockout mice; Immunologi; Immunology; Immunologi;

    Sammanfattning : Induction of collagen-induced arthritis (CIA), an animal model for human rheumatoid arthritis, is dependent on anti-collagen type II (CII) antibodies. The effector mechanism by which autoantibodies contribute to inflammatory reactions in autoimmune diseases is not well understood. LÄS MER

  7. 5. Utilizing Solid Phase Cloning, Surface Display And Epitope Information for Antibody Generation and Characterization

    Författare :Francis Jingxin Hu; Johan Rockberg; John McCafferty; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody engineering; antibody affinity maturation; combinatorial protein engineering; epitope mapping; FACS; HER2; complement C5; Staphylococcal surface display; surface display.; Bioteknologi; Biotechnology;

    Sammanfattning : Antibodies have become indispensable tools in diagnostics, research and as therapeutics. There are several strategies to generate monoclonal antibodies (mAbs) in order to avoid the drawbacks of polyclonal antibodies (pAbs) for therapeutic use. LÄS MER