Sökning: "clonal relationship"
Visar resultat 1 - 5 av 24 avhandlingar innehållade orden clonal relationship.
1. Molecular Interrogation and Functional Studies of Acute Leukemia
Sammanfattning : Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. LÄS MER
2. Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia
Sammanfattning : The aim of this thesis was to analyze the genetic and epigenetic characteristics of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH ALL), the most common type of childhood malignancy. The three original articles presented in this thesis have addressed three major questions regarding HeH ALL: what are the genetic characteristics of the most common structural abnormality – dup(1q)? Are aberrant methylation patterns involved in leukemogenesis? How do diagnostic and relapse samples relate to each other genetically? In article I we found that the proximal breakpoints of dup(1q)-positive Burkitt lymphomas (BL) and pediatric HeH ALLs cluster close to the centromere, suggesting this region to be breakprone, and that five genes on 1q were significantly overexpressed and thus potentially pathogenetically important. LÄS MER
3. Clonal structures and cell interactions in cancer
Sammanfattning : Despite sharing an identical genome, cells of higher order multicellular organisms display a large degree of phenotypic diversity. This diversity is maintained by a sophisticated regulatory machinery that integrates information from both intrinsic and extrinsic factors, ultimately coordinating the appropriate gene expression. LÄS MER
4. Insights into population structure and epidemiology of Phytophthora infestans from Nicaragua
Sammanfattning : Late blight caused by Phytophthora infestans (Mont) de Bary is a constraint to both potato and tomato crops in the northern highlands of Nicaragua. This thesis describes studies on population structure and epidemiology of P. infestans from Nicaragua. The genotypic and phenotypic variation in isolates of P. LÄS MER
5. Cell lineage analysis in humans
Sammanfattning : Delineating a cell’s history, where it came from and what has happened to it, can provide clues as to how tissues and organs are formed and function in the healthy state and in disease. The gold standard for tracing the relationships between cells and their progeny, is performed through prospective labeling with dyes or genetics tags. LÄS MER