Sökning: "classes of score functions"

Hittade 4 avhandlingar innehållade orden classes of score functions.

  1. 1. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Författare :Lars Ängquist; Matematisk statistik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Sammanfattning : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. LÄS MER

  3. 2. Causal Combinatorics : Edges of the Characteristic Imset Polytopes

    Författare :Petter Restadh; Svante Linusson; Liam Solus; James Cussens; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Matematik; Mathematics;

    Sammanfattning : Explaining data in a concise and efficient manner has become increasingly important in today's society. This thesis pertains to the problem of finding causal links within data, and how that can be done from a mathematical perspective. Using the framework of graphical models has several advantages, from interpretability to efficiency. LÄS MER

  4. 3. OMS – Ocular motor score : a clinical method for evaluation and follow-up of ocular motor problems in children

    Författare :Monica Olsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ocular Motor Score OMS ;

    Sammanfattning : Background: Eye movements can be a source of valuable information to clinicians. Different classes of eye movements, i.e. saccades, smooth pursuit (SP) and vestibular eye movements can be distinguished on the basis of how they aid vision. LÄS MER

  5. 4. Vascular and endothelial function in human hypertension, and the importance of the renin-angiotensin-aldosterone system

    Författare :Andreas Jekell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Hypertension induces structural vascular and cardiac changes with increased arterial stiffness and left ventricular (LV) hypertrophy and is major risk factor for cardiovascular morbidity and mortality. The renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system are important for blood pressure regulation and vascular function. LÄS MER