Sökning: "chromosomal integrity"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden chromosomal integrity.

  1. 1. Proteins influencing the integrity of meiotic chromosome dynamics

    Författare :Mary-Rose Hoja; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called synapsis) and recombination between them. LÄS MER

  3. 2. Maintenance of genome integrity via activities of the cohesin network

    Författare :Emma Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Correct segregation of sister chromatids is an important mechanism for keeping the genome intact. The cohesin complex holds the sister chromatids together from the time of their formation during replication, until separation at anaphase and is thereby mediating cohesion between the sister chromatids, essential for correct chromatid segregation. LÄS MER

  4. 3. Structural maintenance of chromsomes : a complex tale of genomic integrity

    Författare :Hanna Betts Lindroos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genomic integrity is an absolute requirement for cell survival. Programmed events such as genome rearrangements and DNA replication can cause lesions in the DNA, as can exogenous agents such as radiation and chemicals. One of the most austere types of lesion is DNA double strand breaks (DBSs). LÄS MER

  5. 4. Human Embryonic Stem Cells; A novel model system for early human development

    Författare :Karin Gertow; Lars Ährlund-Richter; Henrik Semb; Karolinska Institute; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; Human embryonic stem cells; model system; differentiation; xeno-grafting; teratoma; development; karyotype; chromosomal integrity; variant.;

    Sammanfattning : Human embryonic stem cells (HESC) have since their first description in 1998 been recognized as a theoretically endless source of cells capable of differentiation into any somatic cell type. Although great attention has been given to their potential use in cell- based therapy, they are equally important as research tools for studies on early human development, both normal and diseased. LÄS MER

  7. 5. Role of latent EBV genes in the induction of genomic instability in Burkitt’s lymphoma

    Författare :Bettina Gruhne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epidemiological and molecular evidence link Epstein-Barr virus (EBV) infection to a variety of lymphoid and epithelial malignancies but the contribution of the virus to tumorigenesis is unclear. Genomic instability, defined by the establishment of a mutator phenotype and characterized by the occurrence of non-clonal chromosomal aberrations, excessive DNA damage and defects in DNA repair, is the hallmark of malignant transformation. LÄS MER