Sökning: "chromosomal alterations"

Visar resultat 1 - 5 av 81 avhandlingar innehållade orden chromosomal alterations.

1. 1. Genetic Alterations in Lymphoma : with Focus on the Ikaros, NOTCH1 and BCL11B Genes

   Författare :Anneli Karlsson; Peter Söderkvist; Shi-Mei Zhuang; Jan-Ingvar Jönsson; Dan Grandér; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell proliferation; Lymphoma; Znfn1a1; Notch1; Bcl11b; chromosomal regions; Ikaros; B-cell lymphomas; Oncology; Onkologi;

   Sammanfattning : Cell proliferation is a process that is strictly regulated by a large number of proteins. An alteration in one of the encoding genes inserts an error into the regulative protein, which may result in uncontrolled cell growth and eventually tumor formation. LÄS MER

3. 2. Genomic and genetic alterations in endometrial adenocarcinoma

   Författare :Eva Falck; Karin Klinga-Levan; Afrouz Behboudi; Pierre Åhman; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endometrial cancer; Genetic background; BDII rat model; SKY; Chromosomal abreations; Gene expression; Medicine; Medicin; Natural sciences;

   Sammanfattning : The most frequently diagnosed cancer of the female genital tract is cancer of the endometrium (endometrial cancer), ranking fourth among the invasive tumors that affect women in Europe and North America. As most other cancer types, endometrial cancer is a complex genetic disease influenced by both genetic and environmental factors. LÄS MER

4. 3. Molecular Characterisation of Structural Chromosomal Abnormalities Associated with Congenital Disorders

   Författare :Mahmoud R. Mansouri; Niklas Dahl; Hans Van Bokhoven; Uppsala universitet; []
   Nyckelord :Genetics; Chromosomal abnormalities; Mental retardation; Hypospadias and anal malformation; Premature ovarian failure; Autism; Array-CGH; ZDHHC15; Genetik;

   Sammanfattning : Chromosomal abnormalities are defined as changes in the chromosome structure and fall in one of two categories. The first category is numerical alterations while the second category consists of structural abnormalities. Structural chromosomal abnormalities do not always interrupt genes in order to cause disease. LÄS MER

5. 4. Genetic alterations in Scandinavian neuroblastoma tumors

   Författare :Katarina Ejeskär; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; loss of heterozygozity; deletion; 1p; 3p; CDC2L1; TP73; CORT; FHIT;

   Sammanfattning : The results presented here derive from our efforts to find genes and chromosomal regions of interest in the formation and progression of the childhood tumor neuroblastoma.Neuroblastoma is the most common extracranial solid tumor of childhood. LÄS MER

7. 5. Genetic Alterations in Early Onset Breast Cancer

   Författare :Massimiliano Gentile; Anne-Lise Börresen-Dale; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Cancer is in essence a genetic disease, brought about by an accumulation of alterations in genes that encode proteins responsible for the control of cell growth, cell death and the maintenance of genomic integrity. Recent years have seen the unravelling of numerous genes that are targeted in carcinogenesis. LÄS MER