Sökning: "chondrocyte implantation"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden chondrocyte implantation.

  1. 1. Chondrocytes Differentiation- Biological and Biomaterial Perspectives

    Författare :Hanna Stenhamre; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scaffold.; chondrocyte implantation; cartilage tissue engineering; dedifferentiation; redifferentiation;

    Sammanfattning : Articular cartilage is an avascular tissue and once injured it does not heal spontaneously. A successful tissue engineering approach for cartilage reconstruction is autolougus chondrocyte implantation (ACI). LÄS MER

  3. 2. The role of the microenvironment in growth plate and articular chondrocyte differentiation

    Författare :Zelong Dou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : One crucial process during skeletal development is joint formation. It starts with the interzone appearance characterized by high expression of Gdf5, Gli3, Wnt4 and Wnt9a, low expression of Col2a1 of the local compact elongated cells which subsequently give rise to most joint elements including articular cartilage as the ongoing joint cavitation. LÄS MER

  4. 3. Cartilage Tissue Engineering. A study on how to improve cartilage repair

    Författare :Sebastian Concaro; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cartilage tissue engineering Orthopaedics Knee Biomaterials;

    Sammanfattning : One of the first examples of musculoskeletal tissue engineering is autologous chondrocyte implantation (ACI).The first patient with a cartilage lesion was operated with ACI in 1987 and at that time suspension implantation was used. LÄS MER

  5. 4. On the role of signaling pathways in the pathogenesis of osteoarthritis

    Författare :Johan Stenberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Signalling pathways; proteomics; genomics; GDF5; Wnt;

    Sammanfattning : The problem with degenerating cartilage tissues is one of the major causes for disability worldwide. The aetiology of the cartilage degenerating disease osteoarthritis is elusive and considered to be multifactorial. The aim of the present thesis was to find new hypotheses regarding the aetiology of osteoarthritis with focus on signalling pathways. LÄS MER

  7. 5. Promoting the Clinical Relevance of 3D Bioprinting

    Författare :Peter Apelgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3D Bioprinting; Cartilage;

    Sammanfattning : This thesis focuses on the development of methodologies enabling the reconstruction of autologous, functional, and long-term-stable cartilage-like tissue using 3D bioprinting technology and animal experiments. The stability, resilience, and in vivo viability of the printed cells and tissue vascularization, as well as the observed immunogenicity and safety, represent the main issues evaluated and discussed in this thesis. LÄS MER