Sökning: "cholestyramine"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet cholestyramine.

1. 1. On the role of bile acids in chronic diarrhoea

   Författare :Kjell-Arne Ung; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diarrhoea; bile acid malabsorption; steatorrhoea; collagenous colitis; lymphocytic colitis; cholestyramine; long-term; histopathology; symptoms; ileal resection;

   Sammanfattning : Bile acids which promote lipid absorption are actively reabsorbed in the distal ileum. Bile acid malabsorption (BAM) and microscopic colitis (lymphocytic and collagenous) are both associated with chronic watery diarrhoea. LÄS MER

3. 2. Studies on cholesterol homeostasis by modulation of lipoproteins and bile acids

   Författare :Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholesterol; lipoproteins; bile acids; cholestyramine; chenodeoxycholic acid; CYP7A1; HNF4alpha; PCSK9; hepatocytes; ethanol; atherosclerosis; ApoE; thyroid hormone receptor;

   Sammanfattning : Excess plasma cholesterol, in particular high levels of LDL cholesterol, is a major risk factor for the development of atherosclerosis. The liver has a central role in the regulation of cholesterol metabolism: i) a major part of the cholesterol present in the body is synthesized in the liver; ii) the level of plasma lipoproteins is regulated by liver uptake and secretion of these particles and iii) the liver is essential for elimination of cholesterol from the body as such or by its conversion into bile acids. LÄS MER

4. 3. Modulation of bile acid and cholesterol metabolism in health and disease

   Författare :Cecilia Gälman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bile acids - cholesterol - gallstone - cholic acid - cholestyramine - high performance liquid chromatography - species - C4 - 7alpha-hydroxy-4-cholesten-3 -one cholesterol 7alpha-hydroxylase - lipoproteins - hyperlipidemia - statins - resins - diurnal variation - ASBT - 3-hydroxy-3-methylglutaryl coenzyme A;

   Sammanfattning : An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis is a strategy to reduce plasma cholesterol. This partly occurs due to an induction of hepatic LDL receptors. LÄS MER

5. 4. On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients

   Författare :Carl-Gustaf Hillebrant; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bile acid synthesis; biliary lipids; cholesterol synthesis; cholesterol 7a-hydroxylase; cholesterol synthesis inhibitor; chenodeoxycholic acid; cholestyramine; 7a-hydroxy-4-cholesten-3-one; HMG CoA reductase; lathosterol; lipoproteins; lithocholic acid; plasma apheresis; ursodeoxycholic acid;

   Sammanfattning : The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is removed from the human body is via the bile, either as free cholesterol or after transformation to bile acids. LÄS MER

7. 5. Studies on the molecular regulation of bile acids and lipoproteins in human liver

   Författare :Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major risk factor for the development of atherosclerosis. The liver has a central role in cholesterol metabolism and is the only organ capable of a quantitative elimination of cholesterol from the body. LÄS MER