Sökning: "cholera"

Visar resultat 1 - 5 av 89 avhandlingar innehållade ordet cholera.

  1. 1. A mouse model for direct evaluation of cholera vaccines

    Författare :Erik Nygren; Göteborgs universitet; []
    Nyckelord :Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

    Sammanfattning : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). LÄS MER

  3. 2. Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera

    Författare :Stefan Karlsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera; Vibrio cholerae; Serotype; Ogawa; Inaba; Hikojima; Vaccine; Immunogenicity; serotype switching; wbeT;

    Sammanfattning : Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be found all over the world and often causes cholera in places where access to clean water or proper sanitary facilities are limited or compromised. LÄS MER

  4. 3. The enteric nervous sytem and infectious diarrhoea. An experimental study in mouse and rat

    Författare :Shirin Kordasti; Göteborgs universitet; []
    Nyckelord :rotavirus; cholera; secretion; potential difference; enteric nervous system;

    Sammanfattning : Aim: To evaluate the role of the enteric nervous system in one of the most common types of infectious diarrhoea worldwide, rotavirus infection, and to further clarify the mechanisms behind neurally mediated intestinal secretion. Methods: The experiments were performed on neonatal and adult mice and adult rats. Experimental setups: In vitro: 1. LÄS MER

  5. 4. Structural and functional studies of the secreted metalloprotease PrtV from Vibrio cholerae

    Författare :Aaron Edwin; Elisabeth Sauer-Eriksson; Helena Berglund; Umeå universitet; []
    Nyckelord :Cholera; Vibrio cholerae; virulence factors; PrtV; X-ray crystallography; NMR;

    Sammanfattning : Cholera, an acute diarrheal diseases caused by the intestinal infection of the pathogenic bacterium Vibrio cholerae, continues to be a global killer in the world today. PrtV, a secreted zinc metalloprotease, is a potent cytotoxic virulence factor of V. cholerae. LÄS MER

  7. 5. Microarray analyses of the small intestinal mucosa during experimental and clinical cholera

    Författare :Carl-Fredrik Flach; Göteborgs universitet; []
    Nyckelord :Vibrio cholerae; cholera toxin; microarray; transporter; intraepithelial lymphocytes; innate defence;

    Sammanfattning : Vibrio cholerae is a Gram-negative bacterium and the causative agent of cholera. The bacteria infect humans via contaminated water and food, and colonize the upper parts of the small intestine to cause disease. The disease is characterized by watery diarrhoea and most of its clinical features can be attributed to the secreted cholera toxin (CT). LÄS MER