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Visar resultat 1 - 5 av 18 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Childhood acute lymphoblastic leukaemia. Late effects in young adult survivors

    Författare :Marianne Jarfelt; Göteborgs universitet; []
    Nyckelord :childhood acute lymphoblastic leukaemia; adult survivor; GH secretion; body composition; bone mineral density; exercise echocardiography;

    Sammanfattning : Acute lymphoblastic leukaemia (ALL) is the most common malignancy in children. The 5-year survival rate has gradually increased from 5% in early 1970s to over 80% today. Until now most patients have been discharged from further follow up after puberty. LÄS MER

  3. 2. Unwinding the layers of high hyperdiploid childhood acute lymphoblastic leukemia

    Författare :Larissa Helena Moura-Castro; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; acute lymphoblastic leukaemia ALL ; high hyperdiploid ALL; chromatin structure; transcriptional regulation; CTCF; cohesin; clonal heterogeneity;

    Sammanfattning : .... LÄS MER

  4. 3. Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia

    Författare :Peter Jönsson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high dose methotrexate; exposure; dosing algorithms; renal function; cerebrospinal fluid; childhood acute lymphoblastic leukaemia; population pharmacokinetics; relapse risk;

    Sammanfattning : Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. LÄS MER

  5. 4. Late complications of childhood acute lymphoblastic leukaemia (ALL), with special reference to hormone secretion, cardiovascular risk and bone health

    Författare :Cecilia Follin; Lund Medicin; []
    Nyckelord :growth hormone treatment; growth hormone deficiency; cranial radiotherapy; Acute lymphoblastic leukaemia; cardiovascular risk factors; bone mineral density; prolactininsufficiency;

    Sammanfattning : An increased prevalence of cardiovascular (CV) risk factors and cardiac abnormalities has been shown among adult GH deficient ALL survivors subjected to cranial irradiation. The ALL treatment includes many known risk factors for low bone mineral density (BMD), but little is known about pituitary insufficiencies, except for GH deficiency. LÄS MER

  7. 5. Genetic changes in childhood acute lymphoblastic leukaemia and other lymphoid malignancies

    Författare :Teresa Calero Moreno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant transformation of normal cells is the result of defects in cell growth control, differentiation and programmed cell death. It has been convincingly shown that malignant cells carry mutations in the genes controlling these cellular processes. LÄS MER