Sökning: "central nervous system relapse"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden central nervous system relapse.

1. 1. lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools

   Författare :Thomas Olsson Bontell; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histopathology; DNA methylation profiling; DNA methylation-based classification; Diffuse lower grade-glioma; Genomic analysis; Molecular biomarkers; Pediatric glioma;

   Sammanfattning : Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of molecular markers in central nervous system tumors has improved substantially in recent decades. LÄS MER

3. 2. Clinical factors and outcome in T-cell lymphoma: a population-based perspective

   Författare :Fredrik Ellin; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T-cell Lymphoblastic Lymphoma; peripheral T-cell lymphoma; prognostic factors; autologous stem cell transplantation; central nervous system relapse; comorbidity;

   Sammanfattning : The heterogeneous group of T-cell lymphomas consist mostly of aggressive diseasess, with generally unfavourable outcome compared to aggressive B-cell lymphomas following similar therapy. This thesis focus on outcome and risk factors for inferior survival, in an unselected population-based cohort of T-cell lymphoma patients. LÄS MER

4. 3. Factors affecting the pharmacological treatment of bipolar disorder

   Författare :Louise Öhlund; Ursula Werneke; Michael Ott; Mikael Sandlund; Allan Young; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lithium; Bipolar Disorder; Schizoaffective Disorder; Physical Health; Compliance; Medication Adherence; Side Effects; Long Term Adverse Effects; Mood Stabiliser; Admission; Hospitalisation; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Self-Injurious Behaviour; Non-Suicidal Self Injury; Suicide Attempted; Suicide; psykiatri; Psychiatry;

   Sammanfattning : Background: In patients with bipolar disorder, long-term treatment with mood-stabilisers is often required to prevent manic and depressive episodes. At present, our knowledge remains limited regarding factors that influence the outcomes of mood-stabiliser treatment. LÄS MER

5. 4. Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia

   Författare :Peter Jönsson; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high dose methotrexate; exposure; dosing algorithms; renal function; cerebrospinal fluid; childhood acute lymphoblastic leukaemia; population pharmacokinetics; relapse risk;

   Sammanfattning : Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. LÄS MER

7. 5. Diffuse large B-cell lymphoma : population-based studies of relapse and cardiac complications

   Författare :Sara Harrysson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Diffuse large B-cell lymphoma (DLBCL) is an aggressive life-threatening disease, but it is often possible to cure with immunochemotherapy. Not responding to primary treatment or having a relapse is associated with poor prognosis. However, it has not been well described how large the proportion of patients with relapsed/refractory disease is. LÄS MER