Sökning: "cell membrane damage"

Visar resultat 1 - 5 av 123 avhandlingar innehållade orden cell membrane damage.

  1. 1. Pathogen entry mechanisms and endocytic responses to plasma membrane damage

    Författare :Lars Nygård Skalman; Richard Lundmark; Kristian Riesbeck; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocytosis; plasma membrane; pathogens; virus; bacterial membrane vesicles; Helicobacter pylori; adenovirus 37; listeriolysin O; pore-forming toxins; membrane repair;

    Sammanfattning : Endocytosis is a fundamental cellular process by which cells transport material from the outside to the inside of the cell through the formation of membrane invaginations that bud off from the plasma membrane. This process is important for nutrient uptake, regulating cell surface receptors and the overall plasma membrane composition. LÄS MER

  3. 2. Cell Contacts and Airway Epithelial Damage in Asthma

    Författare :Shahida Shahana; Godfried Roomans; Rolf Odselius; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anatomy; Desmosomes; tight junctions; major basic protein; eosinophil; cytokines; epithelial damage.; Anatomi; Anatomy; Anatomi;

    Sammanfattning : Airway epithelial damage is commonly found in asthma patients. Epithelial damage was investigated with special reference to contacts between epithelial cells.Eosinophils, common in allergic asthma, secrete cationic proteins, particularly major basic protein (MBP). LÄS MER

  4. 3. Non-canonical ATG8 conjugation in ESCRT-driven membrane remodeling processes

    Författare :Anastasia Knyazeva; Yao-Wen Wu; Richard Lundmark; Sascha Martens; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ATG8 conjugation; Endosomal Sorting Complex Required for Transport; membrane remodeling; chemical genetics;

    Sammanfattning : ATG8 family proteins have the unique ability to conjugate to membrane lipids. Initially identified as a hallmark of autophagy, ATG8 lipidation is emerging as an important regulator of a growing list of non-degradative cellular functions. LÄS MER

  5. 4. Towards Pharmacological Treatment of Cystic Fibrosis

    Författare :Charlotte Andersson; Aleksander Edelman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; cystic fibrosis; airway epithelium; genotype; CFTR; chloride transport; genistein; phenotype; phenylbutyrate; S-nitrosoglutathione; Cellbiologi; Cell biology; Cellbiologi; entomologi; Entomology;

    Sammanfattning : S-nitrosogluthatione is an endogenous substance, present at decreased levels in the lungs of CF patients and was recently found to induce mature CFTR in airway epithelial CF cell lines. We show that S-nitrosoglutathione in physiological concentrations increases the presence of ΔF508 CFTR in the cell membrane and induces cAMP dependent chloride transport in cystic fibrosis airway epithelial cells. LÄS MER

  7. 5. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7

    Författare :Frida Niss; Anna-Lena Ström; Einar Hallberg; Georg Auberger; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurodegeneration; SCA7; Polyglutamine diseases; RNA binding proteins; Aggregation; Stress granules; Chromatin organization; Quantitative image analysis; Nuclear envelope; Nuclear pore complex; Nucleocytoplasmic transport; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER