Sökning: "caspase 3"

Visar resultat 1 - 5 av 185 avhandlingar innehållade orden caspase 3.

  1. 1. Caspase-3 in lens epithelium

    Författare :Nooshin Talebizadeh; Per Söderberg; Finn Hallböök; Konstantin Galichanin; Michael Wormstone; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ultraviolet radiation; caspase-3; lens; cataract; apoptosis; Immunohistochemistry; spatial distribution; time evolution; modelling; automatic analysis; cell counting; image analysis.; Ophtalmology; Oftalmiatrik;

    Sammanfattning : Purpose: To model the time evolution of active caspase-3 protein expression in a healthy lens, and in a lens exposed to UVR-300 nm (UVR-B). To develop an automated method to classify the fluorescent signal of biomarkers in the lens epithelial cells.Methods: Six-week old Sprague-Dawley rats were used. LÄS MER

  3. 2. Inflammatory Reactions in Peritonitis and Malignant Obstructive Jaundice : Clinical and Experimental Studies with Special Emphasis on the Cellular Immune Response

    Författare :Johanna Österberg; Ulf Haglund; Mikael Ljungdahl; Roland Andersson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; CLP; sepsis; peritonitis; bacterial translocation; malignant obstructive jaundice; Linomide; COX inhibitor; SC-236; indometacin; T lymphocyte; macrophage; mucosa; MLN; gut immune cell distribution; mucosal injury; cytokines; TNF-α; IL-6; IL-10; endotoxin; caspase-3; apoptosis; Kirurgi; Surgery; Kirurgi;

    Sammanfattning : Patients with peritonitis or malignant obstructive jaundice (HPB+) have an increased morbidity and mortality due to sepsis. An altered cell-mediated immunity in the intestinal mucosa might promote gut barrier failure, increased endotoxin and cytokine release and bacterial translocation (BT) in these conditions. LÄS MER

  4. 3. Genetic studies of neuroblastoma with emphasis on the apoptotic pathway

    Författare :Frida Abel; Göteborgs universitet; []
    Nyckelord :child; cancer; neuroectodermal; neural crest; loss of heterozygosity; LOH; bcl-2; mcl-1; apaf-1; caspase-2; caspase-3; caspase-9; PIN; DLC-1; caspase-2;

    Sammanfattning : Aim: The objective of this thesis was to find genes and chromosomal regions involved in neuroblastoma (NB) tumor progression. NB is a childhood tumor of the sympathetic nervous system that generally occurs spontaneously. LÄS MER

  5. 4. Caspase-dependent and caspase-independent neuronal injury in the developing brain

    Författare :Changlian Zhu; Göteborgs universitet; []
    Nyckelord :hypoxia ischemia; neonatal; cell death; caspase; apoptosis-inducing factor; brain; apoptosis; autophagy; nitric oxide;

    Sammanfattning : Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing brain.Methods: Rats or mice were subjected to left common carotid artery ligation plus hypoxia. Animals were sacrificed at certain time points after hypoxia-ischemia. LÄS MER

  7. 5. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Författare :Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER