Sökning: "calnexin"

Hittade 5 avhandlingar innehållade ordet calnexin.

  1. 1. Calreticulins- Calcium-Binding Proteins with Functional Diversity and Evolutionary Duality

    Författare :Staffan Persson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant biochemistry; plant; isoforms; evolution; diversity; differential regulation; chaperone; calnexin; calmegin; calcium; Arabidopsis; calreticulin; Växtbiokemi;

    Sammanfattning : Calreticulin is a multifunctional protein mainly localized in the endoplasmic reticulum in eukaryotic organisms, except yeasts. The protein comprises three distinct regions: the N-terminal N domain, the C-terminal C domain, and the central P domain, reflecting the functional diversity of calreticulin. LÄS MER

  3. 2. Folding and retention of rotavirus glycoproteins in the endoplasmic reticulum

    Författare :Ali Mirazimi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ER; rotavirus; VP7; NSP4; oligosaccharide processing; N-linked glycosylation; protein disulfide isomerase; calnexin; ATP; ER retention;

    Sammanfattning : The endoplasmic reticulum (ER) is a membrane bound organelle composed of a network of cisternae stretching throughout the cytoplasm. Functionally, the ER performs many essential processes, such as glycosylation, and biosynthesis of lipids; it provides a redox potential condition for forming S-S linkages, and a quality control system, and functions as an intracellular calcium store. LÄS MER

  4. 3. Storage organelles that are distinct from the classical granules in human neutrophils

    Författare :Sara Pellmé; Göteborgs universitet; []
    Nyckelord :neutrophil; HL-60 cells; cytoplasts; granules; CXCL-8; ER; phagocytosis; HLA-I; subcellular fractionation; immunogold;

    Sammanfattning : The human neutrophil is a crucial participant in acute inflammation. Appropriate immune response is dependent on rapid direction of phagocytic cells through the tissue, towards the inflammatory focus. Such movement is governed by chemoattractants, e.g. LÄS MER

  5. 4. The quality control of MHC class I antigen presentation

    Författare :Kajsa M Paulsson; Antigen presentation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperone; assembly; COPI; antigenic peptide; TAP; MHC; tapasin; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells. The peptides are generated by proteasomes in the cytosol, then translocated across the membrane of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). LÄS MER

  7. 5. Characterisation of the novel endoplasmic reticulum chaperone ERDJ5

    Författare :Paula Cunnea; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endoplasmic reticulum; chaperone; unfolded protein response; protein folding; disease;

    Sammanfattning : Communication between cells depends to a large extent on interactions between secreted proteins and membrane receptors. Therefore their production and release must be strictly regulated. Proteins that are destined for the extracellular space assemble and fold in the endoplasmic reticulum (ER). LÄS MER