Sökning: "cMyc"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet cMyc.

  1. 1. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

    Författare :Raviprakash Tumkur Sitaram; Göran Roos; Anders Bjartell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; DJ-1; NBS1; PTEN; WT1; cMyc; hTERT; telomerase; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. LÄS MER

  3. 2. Regulatory mechanisms contributing to the homeostasis of normal and malignant hematopoietic cells

    Författare :Harsha Madapura Sekharappa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bone marrow is the site of origin of diverse population of hematological cells with lineage specific function. The different lineages of cells originate from a common progenitor that has a strong self-renewable capability giving rise to myeloid and lymphoid progenitor cells. LÄS MER

  4. 3. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress

    Författare :Malin Fladvad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. LÄS MER

  5. 4. Regulation of the ribosomal RNA transcription by c-MYC oncoprotein

    Författare :Azadeh Arabi; Anthony Wright; Robert White; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; Nucleolus; Proteasome; RNA Polymerase; Cancer;

    Sammanfattning : The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon inhibition of proteasomes, excess c-Myc accumulates primarily in the nucleoli. LÄS MER

  7. 5. Manipulating neural stem cells

    Författare :Malin Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The stem cell field is a fairly young but fast growing scientific field. Our understanding of stem cells has changed tremendously over the last couple of decades. This in mainly due to the development of new techniques that has enabled us to study stem cells from a completely new perspective. LÄS MER