Sökning: "c-kit"

Visar resultat 26 - 30 av 41 avhandlingar innehållade ordet c-kit.

  1. 26. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Författare :Sofie Mohlin; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Sammanfattning : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. LÄS MER

  3. 27. Cellular and Molecular Pathways Governing Hematopoietic Stem Cell Fate

    Författare :Liping Yang; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell; hematopoiesis; bone marrow transplantation; lineage commitment; cytokine; Medicine human and vertebrates ; Clinical genetics; Klinisk genetik; extracellulära vätskor; Hematologi; Medicin människa och djur ; extracellular fluids; Haematology;

    Sammanfattning : Hematopoietic Stem Cells (HSCs) have been defined to have abilities of both self-renewal and multi-lineage differen-tiation. The balance between these abilities is rigorously controlled under steady-state status (homeostasis) and when the normal processes of self-renewal and differentiation become deregulated, a disorder of blood system (such as leukemias) can occur. LÄS MER

  4. 28. Signal Transduction in Mast Cell Migration

    Författare :Magnus Sundström; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; HMC-1; Kit; MAP kinase; mast cells; mastocytosis; p38; SCF; TGF-β; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Mast cells are essential effector cells in the immune system as they release several inflammatory mediators. An accumulation of mast cells has been described in inflammatory conditions such as asthma and allergic rhinitis. LÄS MER

  5. 29. Intervertebral disc regeneration. Studies on stem cell niches and cell transplantation

    Författare :Helena Barreto Henriksson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intervertebral disc stem cells degenerative disc cell transplantation stem cell niches disc degeneration mesenchymal stem cells cell therapy;

    Sammanfattning : Abstract Intervertebral disc regeneration Studies on stem cell niches and cell transplantation Helena Barreto Henriksson Gothenburg 2010 Low back pain is a common condition in the Western world and disc degeneration (DD) is considered a major cause. DD is characterized by dysfunctional cells and decreased matrix production. LÄS MER

  7. 30. Stem cells for cardiac regeneration

    Författare :Ivana Bulatović; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recent studies have demonstrated a turnover of cardiomyocytes throughout the adult life. Whether this regenerative potential is due to proliferation and differentiation of resident stem cells or to the dedifferentiation of adult cardiomyocytes remains unclear. LÄS MER