Sökning: "c-jun"

Visar resultat 1 - 5 av 72 avhandlingar innehållade ordet c-jun.

  1. 1. JNK/c-Jun Signaling and Peripheral Nerve Regeneration

    Författare :Charlotta Lindwall; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuropsykologi; neurofysiologi; neurophysiology; Neurologi; neuropsychology; Neurology; Djurfysiologi; Animal physiology; JNK; signal transduction; nerve regeneration;

    Sammanfattning : The events associated with axonal injury in the peripheral nervous system (PNS) have been described in detail. However, the molecular mechanisms underlying the regenerative response, or neuronal cell death, following axonal injury are poorly understood. LÄS MER

  3. 2. Studies on two transcription regulatory proteins : cellular c-Jun and adenovirus E1A

    Författare :Kerstin Sollerbrant; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adenovirus; EIA; EIB; transcription; CtBP; c-Jun; Gal4;

    Sammanfattning : Adenoviruses cause lytic infections in a range of mammalian cells, but can in certain cases also transform the host cell. The first adenovirus gene to be expressed upon infection is E1A. The E1A gene encodes two major proteins of 243 and 289 amino acids, respectively, both of which serve as key regulators during virus infection. LÄS MER

  4. 3. Cellular mechanisms of taxane therapy in castration resistant prostate cancer

    Författare :Martina Tinzl; Malmö (Abrahamsson) Urologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; chemotherapy; taxane; c-jun; androgen receptor; PSA;

    Sammanfattning : Chemotherapy of castration resistant prostate cancer (CRPC) is based on taxane formulations worldwide. Only 30-50 % of patients respond to this therapy and the exact cellular mechanisms of taxane resistance in PC cells are not fully elucidated. There is convincing evidence that androgen receptor (AR) is affected by exposure to these compounds. LÄS MER

  5. 4. Effects of ethanol on the expression of immediate-early genes in nerve cells

    Författare :Wei-Qun Ding; Institutionen för laboratoriemedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroadaptation; the central nervous system; AP-1; junD; junB; c-jun; fosB; c-fos; neuroblastoma SH-SY5Y; ethanol; immediate-early genes; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Immediate-early genes of the fos and jun families encode proteins that dimerize to form a complex of activator protein 1 and regulate the expression of a number of genes in the nervous system. Ethanol has previously been shown to induce alterations in expression of fos and jun genes in the brain. LÄS MER

  7. 5. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    Författare :Shyam Kumar Gudey; Marene Landström; Urban Lendahl; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; Pathology; patologi;

    Sammanfattning : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. LÄS MER