Sökning: "c-Cbl"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet c-Cbl.

  1. 1. ß2 integrin-induced signal transduction events in human neutrophils

    Författare :Fredrik Melander; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; integrins; signal transduction; Rho GTPases; kinases; c-Cbl; General pathology; patologisk anatomi; pathological anatomy; Patologi allmän ; neutrophils;

    Sammanfattning : Inflammation is a localized protective response in vascularized tissues and can be induced by microbial infection or cell and tissue injury. Polymorphonuclear neutrophils (PMN) are the most common white blood cells and are recognized as major cellular mediators of acute inflammation. LÄS MER

  3. 2. Regulation of PDGFRβ signaling 

    Författare :Piotr Wardęga; Johan Lennartsson; Edvard Smith; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PDGF; HD-PTP; Alix; Cbl; Ub; Fer; Y857; Y771; downregulation; degradation; ubiquitination; activation loop; Cell and molecular biology; Cell- och molekylärbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factor (PDGF) isoforms, which bind to closely related a- and b-tyrosine kinase receptors, induce migration, proliferation, survival and differentiation of mesenchymal cells. They signal by the active receptor attracting Src homology 2 (SH2) domain containing proteins, which subsequently initiate a set of signaling pathways. LÄS MER

  4. 3. The many faces of IGF-1R from cell surface to the nucleus

    Författare :Sandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. LÄS MER

  5. 4. Studies of PDGF receptor signaling in vitro and in vivo

    Författare :Maria Tsioumpekou; Carl-Henrik Heldin; Jean-Baptiste Demoulin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; signaling; cancer; Erk5; kinase; Cbl; ubiquitination; deubiquitinase; pericytes; tumor growth; angiogenesis; low molecular weight inhibitors;

    Sammanfattning : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. LÄS MER

  7. 5. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

    Författare :Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER