Sökning: "burden of disease"

Visar resultat 21 - 25 av 567 avhandlingar innehållade orden burden of disease.

  1. 21. Long-term follow-up after intensive care: Development of an ICU-specific questionnaire

    Författare :Johan Malmgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensive care; critical illness; intensive care unit; quality of life; long-term follow-up; survivorship; health-related quality of life; burden of disease;

    Sammanfattning : Background: With improved results in intensive care comes a shift in focus – from survival to survivorship. Studies show that ICU survivorship includes effects on, for example, mental and physical health, cognition, ADL, ability to return to work, and sensory organ functions. LÄS MER

  3. 22. Health-related quality of life in persons with Parkinson's disease. Aspects of symptoms, caregiving and sense of coherence

    Författare :Marianne Caap-Ahlgren; Geriatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SOC; PDQ-8 and 39; SF-36; GDS; insomnia; caregiving; Parkinson s disease; health-related quality of life; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; Gerontology; Gerontologi;

    Sammanfattning : Abstract Aims: The aim of this thesis was to investigate how the impact of Parkinson’s disease, a chronic neurodegenerative disorder, influences the person’s health-related quality of life. The aim was also to investigate nursing assessment and management of Parkinson’s in elderly persons. LÄS MER

  4. 23. Therapeutic and functional studies in animal models of Alzheimer's disease

    Författare :Astrid Gumucio; Lars Nilsson; Richard Cowburn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; Immunotherapy; IntelliCage; Microtubule; Tau; Alternative splicing; Neuroscience; Neurovetenskap; Medical Cell Biology; Medicinsk cellbiologi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Senile plaques (Aβ) and neurofibrillary tangles (tau) are pathological hallmarks of Alzheimer’s disease (AD). If and how the formation of these deposits are mechanistically linked remains mainly unknown. In recent years, the focus has shifted from insoluble protein deposits to soluble aggregates of Aβ and tau. LÄS MER

  5. 24. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

    Författare :Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. LÄS MER

  7. 25. Towards the Limits – Climate Change Aspects of Life and Health in Northern Sweden : studies of tularemia and regional experiences of changes in the environment

    Författare :Maria Furberg; Maria Nilsson; Anders Johansson; Lars Weinehall; Peter Friberg; Umeå universitet; []
    Nyckelord :Climate change; public health; Indigenous peoples; Sami; reindeer herding; resilience; tularemia; mixed-methods; infectious disease; seroprevalence; ELISA; outbreak investigation; risk factor; ecology; Francisella tularensis; Epidemiology; epidemiologi; folkhälsa; Public health;

    Sammanfattning : BackgroundIndigenous peoples with traditional lifestyles worldwide are considered particularly vulnerable to climate change effects. Large climate change impacts on the spread of infectious vector-borne diseases are expected as a health outcome. LÄS MER