Sökning: "bud development"

Visar resultat 21 - 25 av 26 avhandlingar innehållade orden bud development.

  1. 21. Role of ion and water channels for lung growth in congenital diaphragmatic hernia

    Författare :Andreas Ringman Uggla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Early lung development is based on a continuous cross-talk of growth and transcription factors between the developing lung bud and the surrounding parenchyma. Throughout fetal life, pulmonary growth and differentiation depend on Cl- driven lung liquid secretion. LÄS MER

  3. 22. Effects of growth factors on chondrocyte proliferation and differentiation

    Författare :Caroline Edwall-Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Growth plate cartilage; limb buds; growth factors; proliferation; differentiation; collagens; c-fos; ALP;

    Sammanfattning : Longitudinal bone growth is regulated at the level of growth plate chondrocytes by circulating or locally produced hormones and growth factors. Present investigation focused on the effects of growth hormone (GH) and growth factors on chondrocyte proliferation and differentiation during pre- and postnatal cartilage development. LÄS MER

  4. 23. Morphogen interpretation in the developing nervous system

    Författare :Sanja Kurdija; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Development of the central nervous system relies on the generation of specialized cell types in a tightly controlled spatial and temporal order from neural progenitor cells. Morphogen molecules, secreted by defined sources, spatially organize neural progenitors by inducing discrete expression patterns of cell fate determinant genes in a concentration-dependent manner. LÄS MER

  5. 24. Genetic studies of congenital upper limb anomalies

    Författare :Tobias Laurell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall aim of the work reported in this thesis is to improve epidemiological and genetic knowledge of congenital upper limb anomalies (CULA). To accomplish the specific aims of each paper several different methods and approaches have been used such as register studies, array comparative genome hybridization, Sanger sequencing, exome sequencing and functional studies using Lacz enhancer assay, Zebrafish morpholinos and computational transcription factor binding site prediction. LÄS MER

  7. 25. Characterisation of an in vitro dissolution method for assessment of novel pulmonary drug delivery systems : With a focus on controlled release systems

    Författare :Irès van der Zwaan; Göran Frenning; Per Hansson; Rebecca Fransson; Alessandra Rossi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug delivery; in vitro dissolution; mechanistic model; controlled release; physiologically based biopharmaceutics modelling;

    Sammanfattning : Pulmonary drug delivery has been used for decades to treat local diseases like asthma. When using the pulmonary route to deliver drugs, several important lung features are being used, such as a large surface area available for absorption, high organ vascularization, and a thin blood-alveolar barrier. LÄS MER