Sökning: "bioinformatics analysis"

Visar resultat 1 - 5 av 357 avhandlingar innehållade orden bioinformatics analysis.

1. 1. A Study in RNA Bioinformatics : Identification, Prediction and Analysis

   Författare :Eva Freyhult; David Ardell; Robert Giegerich; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA; bioinformatics; secondary structure; structure prediction; dynamic programming; energy landscape; homology search; sequence logo; tRNA; Bioinformatics; Bioinformatik;

   Sammanfattning : Research in the last few decades has revealed the great capacity of the RNA molecule. RNA, which previously was assumed to play a main role only as an intermediate in the translation of genes to proteins, is today known to play many important roles in the cell in addition to that as a messenger RNA and transfer RNA, including the ability to catalyze reactions and gene regulations at various levels. LÄS MER

3. 2. Copy Number Analysis of Cancer

   Författare :Markus Mayrhofer; Anders Isaksson; Simon Tavaré; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chromosomes; oncology; bioinformatics; Bioinformatik; Bioinformatics; Oncology; Onkologi; Clinical Genetics; Klinisk genetik;

   Sammanfattning : By accurately describing cancer genomes, we may link genomic mutations to phenotypic effects and eventually treat cancer patients based on the molecular cause of their disease, rather than generalizing treatment based on cell morphology or tissue of origin.Alteration of DNA copy number is a driving mutational process in the formation and progression of cancer. LÄS MER

4. 3. A Bioinformatics Study of Human Transcriptional Regulation

   Författare :Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

   Sammanfattning : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. LÄS MER

5. 4. Grid and High-Performance Computing for Applied Bioinformatics

   Författare :Jorge Andrade; Jacob Odeberg; Luciano Milanesi; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Grid computing; bioinformatics; genomics; proteomics; Bioinformatics; Bioinformatik;

   Sammanfattning : The beginning of the twenty-first century has been characterized by an explosion of biological information. The avalanche of data grows daily and arises as a consequence of advances in the fields of molecular biology and genomics and proteomics. LÄS MER

7. 5. Pathway analysis: methods and perspectives

   Författare :Gustavo Stolf Jeuken; Lukas Käll; Mika Gustafsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pathway analysis; mutual information; survival analysis; enrichment analysis; transcriptomics.; Biotechnology; Bioteknologi;

   Sammanfattning : The amount of data being generated by high throughput molecular biology experiments grows every day, both in quantity and quality. With this comes the desire to have more powerful and comprehensive methods for statistical analysis that have been developed with the nature of this data in mind. LÄS MER