Sökning: "bicelle"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet bicelle.

1. 1. Taming the Griffin : Membrane interactions of peripheral and monotopic glycosyltransferases and dynamics of bacterial and plant lipids in bicelles

   Författare :Jobst Liebau; Lena Mäler; Charles Sanders; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane; bicelle; lipid; detergent; lipopolysaccharide; glycosyltransferase; WaaG; fluorescence; circular dichroism; NMR; paramagnetic relaxation enhancement; model-free approach; dynamics; Biophysics; biofysik;

   Sammanfattning : Biological membranes form a protective barrier around cells and cellular compartments. A broad range of biochemical processes occur in or at membranes demonstrating that they are not only of structural but also of functional importance. One important class of membrane proteins are membrane-associated glycosyltransferases. LÄS MER

3. 2. Structural Insights at Sub-Ångstrom, Medium and Low Resolution: Crystallization of Trypsin, Bacterioferritin, Photosynthetic Reaction Center, and Photosynthetic Core Complex

   Författare :Weixiao Yuan Wahlgren; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein crystallization; cubic phase; sponge phase; bicelle; trypsin; bacterioferritin; reaction center; core complex; photosynthesis;

   Sammanfattning : The catalytic action of serine proteases depends on the interplay of a nucleophile, a general base and a general acid. The catalytic triad is composed of serine, histidine and aspartate residues. The serine acts as a nucleophile while the histidine plays a dual role as the general base or acid at different steps of the reaction. LÄS MER

4. 3. The Application of isotropic bicelles as model membranes

   Författare :August Andersson; Lena Mäler; G Arthur III Palmer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bicelle; membrane; peptide; spectroscopy; NMR; Molecular biophysics; Molekylär biofysik;

   Sammanfattning : Isotropic bicelles are disc-shaped aggregates of lipids and detergents, and are suitable model systems for high-resolution NMR studies of membrane-interacting peptides. In this thesis the structures for the two peptides motilin and transportan were determined by homonuclear 1H methods in the presence of bicelles, and the structure of the bovine prion protein peptide (bPrPp) was solved in the presence of DHPC micelles. LÄS MER

5. 4. Membrane interactions of glycosyltransferases

   Författare :Jobst Liebau; Lena Mäler; Christofer Lendel; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lipid; bicelle; glycosyltransferase; NMR; Biophysics; biofysik;

   Sammanfattning : Many important biological processes occur near or in membranes. The role of membranes is not merely confined to compartmentalization, they also form the matrix for membrane associated proteins and are of functional importance. Membrane associated proteins on the other hand require specific membrane properties for proper function. LÄS MER

7. 5. Membrane Induced Structure in Transmembrane Signaling Proteins and Peptides : Peptide–Lipid Interactions Studied by Spectroscopic Methods

   Författare :Sofia E. Unnerståle; Lena Mäler; Jason Schnell; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; paddle domain; voltage gating; voltage sensor domain; micelle; phospholipid bicelle; solution structure; HAMP domain; nuclear magnetic resonance spectroscopy; circular dichroism spectroscopy; nonspecific interaction; Biophysics; biofysik;

   Sammanfattning : Biological membranes, defining the boundary of cells and eukaryotic organelles, are mainly composed of lipids and membrane proteins. Interactions between these lipids and proteins are needed to preserve the tight seal of the membrane, but also to induce structure for proper function in many membrane proteins. LÄS MER