Sökning: "axonal degeneration"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden axonal degeneration.

  1. 1. Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects

    Författare :Michael Jonsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; white matter changes; vascular factors; cognitive impairment; neuropsychiatric symptoms; cerebrospinal fluid biomarkers; demyelination; axonal degeneration;

    Sammanfattning : Cerebral white matter changes (WMC), detected with computed tomography (CT) or magnetic resonance imaging (MRI), represent a common condition in elderly people. However, the prognostic, symptomatological and biochemical constituents of WMC are only partially known. LÄS MER

  3. 2. Neuroprotection and axonal regeneration after peripheral nerve injury

    Författare :Dag Welin; Lev N. Novikov; Lars B. Dahlin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dorsal root ganglion; Motoneuron; Axonal reaction; Peripheral nerve injury; Nerve regeneration; N-acetylcysteine; Hand surgery; Handkirurgi; Anatomy; Anatomi; anatomi; Human Anatomy; handkirurgi; hand surgery;

    Sammanfattning : Following microsurgical reconstruction of injured peripheral nerves, severed axons are able to undergo spontaneous regeneration. However, the functional result is always unsatisfactory with poor sensory recovery and reduced motor function. LÄS MER

  4. 3. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

    Författare :Michael Jewett; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER

  5. 4. On optic nerve injury : experimental studies on axonal regeneration in the adult mammalian CNS

    Författare :Marcus Ohlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Astroglia; axon; degeneration; glial scar; immunohistochemistry; macrophage; methylprednisolone; microglia; neurosurgery; optic nerve; rat; regeneration and visual evoked potentials;

    Sammanfattning : Optic nerve injury may occur after a trauma to the head and in many cases it causes partial or total blindness. Today, these patients cannot be offered any specific treatment to restore visual function. LÄS MER

  7. 5. Intracranial facial nerve lesion : experimental study on neural degeneration and its treatment

    Författare :Per Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis was to develop an experimental model that would generate extensive motor neuronal degeneration in adult rats, and furthermore to study mechanisms causing nerve cell death and effects of putative neuroprotective compounds. The facial nerve was chosen because it is well characterized and allows evaluation of functional recovery by analyzing vibrissae movements. LÄS MER